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九综合征的罕见诊断:临床、影像学表现及文献综述

A rare diagnosis of nine syndrome: Clinical, imaging findings, and literature review.

作者信息

Ng Chin-Yee, Yong Geng-Yi, Ngai Jia-Jeane, Zainal-Abidin Zairah Binti

机构信息

Department of Ophthalmology, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia.

Department of Ophthalmology, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

Taiwan J Ophthalmol. 2023 Feb 1;14(3):431-436. doi: 10.4103/tjo.TJO-D-22-00092. eCollection 2024 Jul-Sep.

DOI:10.4103/tjo.TJO-D-22-00092
PMID:39430356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11488798/
Abstract

In this article, we reported a rare case of nine syndrome, which is characterized by clinical signs of the one-and-a-half syndrome, ipsilateral facial palsy, contralateral hemiparesis, hemihypesthesia, or ataxia. A 44-year-old male presented with sudden onset of double vision for 3 days. Examination revealed left horizontal gaze palsy, internuclear ophthalmoplegia, left lower motor neuron facial nerve palsy with right hemiplegia, and hemihypesthesia. Magnetic resonance imaging brain showed evidence of acute infarction at the left paramedian pons. Magnetic resonance angiography revealed a beaded small-caliber basilar artery suggestive of intracranial vasculopathy in the posterior circulation. The patient has been treated with an antiplatelet and lipid-lowering agent. His right hemiparesis has improved, but the ocular motility and left facial paresis persisted. The literature reviews of 14 cases of nine syndrome were discussed, and the biography background, clinical pictures, etiology, neuroimaging, treatment, and recovery status were described.

摘要

在本文中,我们报告了一例罕见的九联综合征病例,其特征为一个半综合征的临床体征、同侧面部麻痹、对侧偏瘫、偏身感觉减退或共济失调。一名44岁男性突发复视3天。检查发现左侧水平凝视麻痹、核间性眼肌麻痹、左侧下运动神经元性面神经麻痹伴右侧偏瘫及偏身感觉减退。脑部磁共振成像显示左侧脑桥旁正中急性梗死迹象。磁共振血管造影显示基底动脉呈串珠样小口径改变,提示后循环颅内血管病变。该患者接受了抗血小板和降脂药物治疗。其右侧偏瘫有所改善,但眼球运动和左侧面部麻痹仍持续存在。本文讨论了14例九联综合征的文献综述,并描述了病例背景、临床表现、病因、神经影像学、治疗及恢复情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/11488798/83cf9db2cc0b/TJO-14-431-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/11488798/4773d66fb391/TJO-14-431-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/11488798/d7efeeb90f7f/TJO-14-431-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/11488798/ddfcb88883a8/TJO-14-431-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/11488798/83cf9db2cc0b/TJO-14-431-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/11488798/4773d66fb391/TJO-14-431-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/11488798/d7efeeb90f7f/TJO-14-431-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/11488798/ddfcb88883a8/TJO-14-431-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/11488798/83cf9db2cc0b/TJO-14-431-g004.jpg

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本文引用的文献

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Atypical "nine" syndrome in bilateral pontine infarction: A case report.双侧脑桥梗死中的非典型“九”综合征:一例报告
Medicine (Baltimore). 2019 Jul;98(28):e16378. doi: 10.1097/MD.0000000000016378.
2
"Eight and a half" and "nine syndrome" rare presentation of pontine lesions; case reports and review of literature.“八点半”和“九点综合征”:桥脑病变的罕见表现;病例报告及文献综述
Iran J Neurol. 2018 Oct 7;17(4):189-191.
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Nine syndrome.九种综合征。
Acta Neurol Belg. 2019 Sep;119(3):475-476. doi: 10.1007/s13760-019-01151-1. Epub 2019 May 17.
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Nine Syndrome: Case Report and Review of Clinical Signs in Internuclear Ophthalmoplegia.九综合征:核间性眼肌麻痹临床体征的病例报告及综述
Ann Indian Acad Neurol. 2018 Oct-Dec;21(4):325-327. doi: 10.4103/aian.AIAN_118_18.
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Nine syndrome in a patient with systemic lupus erythematosus.
Can J Ophthalmol. 2018 Apr;53(2):e52-e55. doi: 10.1016/j.jcjo.2017.07.018. Epub 2017 Sep 22.
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Case report of a patient with 'one-and-a-half plus syndrome: nine syndrome'.一例“1.5加综合征:九综合征”患者的病例报告
Oxf Med Case Reports. 2018 Jan 25;2018(1):omx085. doi: 10.1093/omcr/omx085. eCollection 2018 Jan.
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Teaching Video Neuro: Nine syndrome in inferior paramedian pontine infarction: More than meets the eye.教学视频神经学:脑桥旁正中下部梗死的九种综合征:不止于所见。
Neurology. 2017 Aug 22;89(8):e95-e96. doi: 10.1212/WNL.0000000000004271.
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Association of Eyelid Position and Facial Nerve Palsy With Unresolved Weakness.眼睑位置及面神经麻痹与未缓解的肌无力的关联
JAMA Facial Plast Surg. 2016 Sep 1;18(5):379-84. doi: 10.1001/jamafacial.2016.0533.
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"Nine" syndrome: A new neuro-ophthalmologic syndrome: Report of two cases.“九”综合征:一种新的神经眼科综合征:两例报告
Ann Indian Acad Neurol. 2015 Jul-Sep;18(3):335-7. doi: 10.4103/0972-2327.157180.
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