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通过水凝胶包裹的G-Rh2疫苗和全身免疫疗法重塑肿瘤免疫微环境。

Remodeling the tumor immune microenvironment through hydrogel encapsulated G-Rh2 vaccine and systemic immunotherapy.

作者信息

Li Chunhua, Lei Dan, Huang Yudong, Jing Yuanhao, Wang Wanru, Cen Lanqi, Wei Zijian, Chen Anni, Feng Xiaoyu, Wang Yushu, Yu Lixia, Chen Ying, Li Rutian

机构信息

The Comprehensive Cancer Center, Nanjing Drum Tower Hospital, Clinical College of Nanjing Drum Tower Hospital, Nanjing University of Chinese Medicine, Nanjing, 210008, China.

State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, China.

出版信息

Mater Today Bio. 2024 Sep 27;29:101281. doi: 10.1016/j.mtbio.2024.101281. eCollection 2024 Dec.

DOI:10.1016/j.mtbio.2024.101281
PMID:39430571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11489055/
Abstract

Ginsenoside Rh2 (G-Rh2) is a vital bioactive compound in Traditional Chinese Medicine, celebrated for its strong pharmacological properties, particularly its potent antitumor effects. However, its poor water solubility and limited bioavailability have necessitated the development of a novel drug delivery method. In this study, we utilized an indocyanine green carboxylic acid-hydroxypropyl cellulose-abietic acid-bovine serum albumin hydrogel (ICG-HPC-AA/BSA hydrogel) as a tumor vaccine to enhance the permeability, retention, and tumor-targeted therapeutic efficacy of G-Rh2. We examined the therapeutic impact of a G-Rh2-loaded hydrogel combined with systemic PD-1 antibody treatment in murine models of H22 liver cancer and CT26 colon cancer. Additionally, we explored the immune microenvironment of the tumors influenced by this vaccination strategy.

摘要

人参皂苷Rh2（G-Rh2）是中药中一种重要的生物活性化合物，因其强大的药理特性而闻名，尤其是其显著的抗肿瘤作用。然而，其水溶性差和生物利用度有限，因此需要开发一种新型药物递送方法。在本研究中，我们利用吲哚菁绿羧酸-羟丙基纤维素-松香酸-牛血清白蛋白水凝胶（ICG-HPC-AA/BSA水凝胶）作为肿瘤疫苗，以提高G-Rh2的通透性、滞留性和肿瘤靶向治疗效果。我们在H22肝癌和CT26结肠癌小鼠模型中研究了负载G-Rh2的水凝胶与全身PD-1抗体治疗联合使用的治疗效果。此外，我们还探讨了这种疫苗接种策略对肿瘤免疫微环境的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/8bac8efe85c8/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/fc9a3b38b585/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/243921119033/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/8e3f5f102da1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/3dbc028180a5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/a70e04a6a1d5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/785cf60f31fc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/b9d903bce6e8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/ef950adddfc3/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/f1b317d38382/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/dc375d9b6df6/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/8bac8efe85c8/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/fc9a3b38b585/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/243921119033/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/8e3f5f102da1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/3dbc028180a5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/a70e04a6a1d5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/785cf60f31fc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/b9d903bce6e8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/ef950adddfc3/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/f1b317d38382/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/dc375d9b6df6/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73da/11489055/8bac8efe85c8/gr9.jpg

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