Ednalino Kimberly Anne G, Yap-Silva Claudine
Department of Dermatology, Philippine General Hospital, University of the Philippines Manila.
Acta Med Philipp. 2024 Sep 30;58(17):106-109. doi: 10.47895/amp.v58i17.7501. eCollection 2024.
Alopecia resulting from radiation exposure occurs 2-8 weeks after exposure. It can be temporary or permanent depending on the dose of exposure. Alopecia following fluoroscopy-guided procedures are increasing in frequency. We report the case of a 22-year-old female who underwent fluoroscopically-guided embolization of an arteriovenous malformation. Twelve days after embolization, significant hair shedding was noted, resulting in a large rectangular hairless patch with no erythema or pain on the irradiated site. Hair pull test was positive and the hair mount showed dystrophic anagen hairs. Hair tug test was negative. Trichoscopy showed yellow dots, black dots, vellus hairs, and flame hairs. Histopathologic examination showed an increase in catagen and telogen hairs. On review of the procedure, she received a total peak skin dose of 4.67 Gray from the procedure. The diagnosis of radiation-induced alopecia was made and topical minoxidil was started, resulting in complete hair growth after six months. Patients undergoing fluoroscopy-guided procedures should have adequate follow-up weeks to months post-procedure to monitor for skin and hair reactions. Physicians should also consider delayed radiation reactions in patients with a history of radiation exposure. Safety protocols must be in place, and measures should be done to minimize the dose delivered.
辐射暴露导致的脱发在暴露后2至8周出现。根据暴露剂量,脱发可能是暂时的或永久性的。透视引导下操作后出现脱发的频率正在增加。我们报告了一例22岁女性,她接受了透视引导下的动静脉畸形栓塞术。栓塞术后12天,发现明显脱发,在照射部位形成一个大的长方形无毛区,无红斑或疼痛。拔毛试验呈阳性,毛发镜检显示生长期毛发营养不良。毛发牵拉试验呈阴性。毛发镜检查显示有黄点、黑点、毳毛和火焰状毛发。组织病理学检查显示退行期和休止期毛发增多。回顾该操作过程,她从该操作中接受的皮肤总峰值剂量为4.67戈瑞。诊断为放射性脱发,并开始外用米诺地尔,6个月后毛发完全生长。接受透视引导下操作的患者在术后应进行足够的随访,随访时间为几周至几个月,以监测皮肤和毛发反应。对于有辐射暴露史的患者,医生也应考虑延迟辐射反应。必须制定安全协议,并采取措施尽量减少辐射剂量。