Besson W T, Kirby M L, Van Mierop L H, Teabeaut J R
Circulation. 1986 Feb;73(2):360-4. doi: 10.1161/01.cir.73.2.360.
Removal of premigratory neural crest over somites 1 through 3 in chick embryos has been shown previously to result in a significant incidence of persistent truncus arteriosus. In the present study, single somite-length pieces of premigratory neural crest were removed unilaterally at slightly different embryonic ages. These lesions resulted in a number of different heart defects. Two defects, ventricular septal defect and double outlet right ventricle, were significantly correlated with the location of neural crest removed. The stage at which the ablation was performed was important in determining the incidence but not the type of defects.
先前已表明，去除鸡胚中第1至3体节上方的迁移前神经嵴会导致相当比例的持续性动脉干。在本研究中，在稍有不同的胚胎发育阶段单侧去除单个体节长度的迁移前神经嵴片段。这些损伤导致了许多不同的心脏缺陷。室间隔缺损和右心室双出口这两种缺陷与去除神经嵴的位置显著相关。进行切除的阶段在确定缺陷的发生率方面很重要，但对缺陷类型并无影响。
