Lockitch G, Wittmann B K, Snow B E, Campbell D J
Clin Chem. 1986 Feb;32(2):361-3.
We analyzed amniotic fluid from 91 pregnancies (estimated gestational age range 31 to 41 weeks), using the Lumadex-FSI Fetal Lung Maturity test (Beckman Instruments), and also determining phosphatidylglycerol content, the lecithin/sphingomyelin ratio, and foam stability index by the "shake test," and compared results with newborn outcome. Five of 64 babies born within 72 h of testing developed hyaline membrane disease. Except for the lecithin/sphingomyelin ratio, the predictive value of a negative test was 100% but that of a positive test was less than 50%. Use of all four tests did not offer diagnostic advantage over the use of Lumadex-FSI alone. For the laboratory that infrequently assesses fetal lung maturity, we believe the sealed cassette format of the Lumadex-FSI will permit better quality assurance than the shake test. The Lumadex-FSI test is intended to provide a graded estimate of positive risk for hyaline membrane disease, but more data from different centers and patient populations are needed to establish reliable predictive values.
我们使用Lumadex-FSI胎儿肺成熟度检测（贝克曼仪器公司），对91例妊娠（估计孕周范围为31至41周）的羊水进行了分析，同时通过“振荡试验”测定了磷脂酰甘油含量、卵磷脂/鞘磷脂比值和泡沫稳定性指数，并将结果与新生儿结局进行了比较。在检测后72小时内出生的64例婴儿中有5例发生了透明膜病。除卵磷脂/鞘磷脂比值外，检测结果为阴性时的预测价值为100%，但检测结果为阳性时的预测价值小于50%。使用所有四项检测方法与单独使用Lumadex-FSI相比，并无诊断优势。对于不常评估胎儿肺成熟度的实验室，我们认为Lumadex-FSI的密封盒式检测形式比振荡试验能提供更好的质量保证。Lumadex-FSI检测旨在对透明膜病的阳性风险提供分级评估，但需要来自不同中心和患者群体的更多数据来确定可靠的预测价值。
