Department of Physical Medicine & Rehabilitation, and Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA.
Centro de Investigación Biomédica de Michoacán - Instituto Mexicano del Seguro Social, Morelia, Mexico.
Adv Neurobiol. 2024;42:147-163. doi: 10.1007/978-3-031-69832-3_7.
Pediatric traumatic brain injury (TBI) is a significant healthcare issue, but potential treatments are absent despite robust investigation in several clinical trials. Factors attributed to clinical TBI, such as heterogeneity of injury and single-dose pharmacological treatments as well as timing of administration, may be reasons for the negative studies. Preclinical models of TBI can reduce some of the impediments by highlighting differences in injury depending on injury severity and location and by conducting dose response studies, thus providing better therapeutic targets and pharmacological profiles for clinical use. In this chapter, there were sufficient reports to make comparisons between the models in terms of pathophysiology, behavioral dysfunction, and the efficacy of therapeutic interventions. The models used to date include controlled cortical impact (CCI), weight drop, fluid percussion, and abusive head trauma. Several therapeutics were identified after CCI injury but none in the other models, which underscores the need for studies evaluating the therapies reported after CCI injury as well as novel potential approaches.
儿科创伤性脑损伤 (TBI) 是一个重大的医疗保健问题，但尽管在几项临床试验中进行了深入研究，仍缺乏潜在的治疗方法。导致临床 TBI 的因素，如损伤的异质性、单剂量药物治疗以及给药时间，可能是研究结果为阴性的原因。TBI 的临床前模型可以通过强调损伤严重程度和位置的差异以及进行剂量反应研究来减少一些障碍，从而为临床应用提供更好的治疗靶点和药物特征。在这一章中，有足够的报告可以根据病理生理学、行为功能障碍和治疗干预的疗效对这些模型进行比较。迄今为止使用的模型包括皮质控制撞击 (CCI)、重物跌落、液压冲击和虐待性头部创伤。CCI 损伤后确定了几种治疗方法，但其他模型中没有，这突出表明需要研究评估 CCI 损伤后报告的治疗方法以及新的潜在方法。
