偏头痛患者中，Syn T2-FLAIR和Syn DIR与传统T2-FLAIR在显示白质高信号方面的比较。
Comparison of Syn T2-FLAIR and Syn DIR with conventional T2-FLAIR in displaying white matter hyperintensities in migraine patients.
作者信息
Liu Zhen-Zhen, Yu Hai-Yang, Li Yuan-Hui, Zhang Zhi-Cheng, Zhao Bin-Liang, Zhang Jie, Guo Ruo-Mi
机构信息
Department of Radiology, the Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, People's Republic of China.
Department of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
出版信息
Neuroradiology. 2025 Jan;67(1):49-56. doi: 10.1007/s00234-024-03477-x. Epub 2024 Oct 21.
OBJECTIVE
Young migraine patients often present with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI). This study aimed to analyze whether synthetic (Syn) T2-FLAIR and Syn double inversion recovery (DIR) can reveal WMHs more clearly and sensitively than conventional T2-FLAIR.
MATERIALS AND METHODS
Conventional MRI and Syn MRI data from 50 young migraine patients were analyzed prospectively. WMHs in each anatomical region (periventricular, deep white matter, and juxtacortical) were recorded separately. The differences in the clarity of lesion boundaries and the number of lesions displayed in the three sequences in the same anatomical region were analyzed.
RESULTS
A total of 80 (periventricular area, 15; deep white matter, 31; juxtacortical area, 34), 163 (17, 50, 96), and 134 (18, 42, 74) lesions were observed with conventional T2-FLAIR, Syn T2-FLAIR, and Syn DIR, respectively. Syn T2-FLAIR and Syn DIR can show lesions more clearly than conventional T2-FLAIR (all P < 0.001). There was no significant difference in the number of lesions observed in the periventricular white matter among the three sequences (P = 0.159, 0.083, 0.322). Syn T2-FLAIR and Syn DIR can detect more lesions in the deep white matter than conventional T2-FLAIR (P < 0.001, P = 0.006). Syn T2-FLAIR revealed more lesions in the juxtacortical white matter than Syn DIR and conventional T2-FLAIR imaging (all P < 0.001), and conventional T2-FLAIR revealed the fewest lesions (P < 0.001).
CONCLUSION
Syn T2-FLAIR and Syn DIR sequences can clearly and sensitively detect WMHs, especially in deep and juxtacortical white matter areas.
目的
年轻偏头痛患者在磁共振成像（MRI）上常出现白质高信号（WMHs）。本研究旨在分析合成（Syn）T2-FLAIR和Syn双反转恢复（DIR）序列是否比传统T2-FLAIR序列能更清晰、更敏感地显示WMHs。
材料与方法
前瞻性分析50例年轻偏头痛患者的传统MRI和Syn MRI数据。分别记录每个解剖区域（脑室周围、深部白质和皮质下）的WMHs。分析同一解剖区域三个序列中病变边界清晰度和显示病变数量的差异。
结果
传统T2-FLAIR、Syn T2-FLAIR和Syn DIR序列分别观察到80个（脑室周围区域15个、深部白质31个、皮质下区域34个）、163个（17个、50个、96个）和134个（18个、42个、74个）病变。Syn T2-FLAIR和Syn DIR序列比传统T2-FLAIR序列能更清晰地显示病变（所有P＜0.001）。三个序列在脑室周围白质中观察到的病变数量无显著差异（P = 0.159、0.083、0.322）。Syn T2-FLAIR和Syn DIR序列在深部白质中比传统T2-FLAIR序列能检测到更多病变（P＜0.００1，P = 0.006）。Syn T2-FLAIR序列在皮质下白质中比Syn DIR和传统T2-FLAIR成像显示出更多病变（所有P＜0.001），而传统T2-FLAIR序列显示的病变最少（P＜0.001）。
结论
Syn T2-FLAIR和Syn DIR序列能清晰、敏感地检测WMHs，尤其是在深部和皮质下白质区域。
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