偏头痛与中风风险的关联：系统评价和荟萃分析。
Association between migraine and risk of stroke: a systematic review and meta-analysis.
机构信息
Department of Acupuncture, Beijing Huguosi Traditional Chinese Medicine Hospital, affiliated to Beijing University of Chinese Medicine, No. 83 Mianhua Hutong, Xicheng District, Beijing, 100035, China.
出版信息
Neurol Sci. 2022 Aug;43(8):4875-4889. doi: 10.1007/s10072-022-06074-z. Epub 2022 Apr 22.
BACKGROUND
Results regarding the association between migraine and risk of stroke are inconsistent.
METHODS
A literature search of the databases (Web of Science, Google Scholar and PubMed) was made before December 2021. STATA 12.0 software was used. Odds ratios (ORs) or relative risks (RRs) and their 95% confidence intervals (CIs) regarding migraine and risk of stroke were computed.
RESULTS
Migraine was associated with increased risks of total stroke, ischemic stroke (IS) and haemorrhagic stroke (HS) (total stroke: OR/RR = 1.62; 95% CI: 1.44-1.83, I = 95.8%, p < 0.001; IS: OR/RR = 1.70; 95% CI: 1.47-1.98, I = 96.1%, p < 0.001; HS: OR/RR = 1.35; 95% CI: 1.11-1.63, I = 85.7%, p < 0.001). Migraine with aura was related to increased risks of total stroke, IS and HS (total stroke: OR/RR = 1.95; 95% CI: 1.62-2.34, I = 89.7%, p < 0.001; IS: OR/RR = 2.17; 95% CI: 1.78-2.64, I = 89.2%, p < 0.001; HS: OR/RR = 1.30; 95% CI: 1.04-1.62, I = 46.3%, p = 0.114). Migraine without aura was related to increased risks of total stroke, IS and HS (total stroke: OR/RR = 1.35; 95% CI: 1.18-1.55, I = 85.4%, p < 0.001; IS: OR/RR = 1.34; 95% CI: 1.11-1.62, I = 87.8%, p < 0.001; HS: OR/RR = 1.29; 95% CI: 1.04-1.61, I = 64.8%, p = 0.023).
CONCLUSIONS
Migraine is associated with a higher risk of total stroke and IS. However, the association between migraine and risk of HS is with more uncertainty.
背景
偏头痛与中风风险之间的关联结果不一致。
方法
在 2021 年 12 月之前，我们对数据库（Web of Science、Google Scholar 和 PubMed）进行了文献检索。使用 STATA 12.0 软件计算偏头痛与中风风险之间的比值比（OR）或相对风险（RR）及其 95%置信区间（CI）。
结果
偏头痛与总卒中、缺血性卒中（IS）和出血性卒中（HS）的风险增加相关（总卒中：OR/RR=1.62；95%CI：1.44-1.83，I=95.8%，p<0.001；IS：OR/RR=1.70；95%CI：1.47-1.98，I=96.1%，p<0.001；HS：OR/RR=1.35；95%CI：1.11-1.63，I=85.7%，p<0.001）。有先兆偏头痛与总卒中、IS 和 HS 的风险增加相关（总卒中：OR/RR=1.95；95%CI：1.62-2.34，I=89.7%，p<0.001；IS：OR/RR=2.17；95%CI：1.78-2.64，I=89.2%，p<0.001；HS：OR/RR=1.30；95%CI：1.04-1.62，I=46.3%，p=0.114）。无先兆偏头痛与总卒中、IS 和 HS 的风险增加相关（总卒中：OR/RR=1.35；95%CI：1.18-1.55，I=85.4%，p<0.001；IS：OR/RR=1.34；95%CI：1.11-1.62，I=87.8%，p<0.001；HS：OR/RR=1.29；95%CI：1.04-1.61，I=64.8%，p=0.023）。
结论
偏头痛与总卒中和 IS 风险增加相关。然而，偏头痛与 HS 风险之间的关联存在更多的不确定性。
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