Reece Jeanette, Jelinek George A, Milanzi Elasma, Simpson-Yap Steve, Neate Sandra L, Taylor Keryn L, Jelinek Pia L, Davenport Rebekah, Bevens William, Yu Maggie
Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.
Biostatistics Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.
Neurol Sci. 2025 Feb;46(2):835-844. doi: 10.1007/s10072-024-07811-2. Epub 2024 Oct 21.
Modifiable lifestyle risk factors for progression of multiple sclerosis (MS) have been increasingly studied. This study employed a single-group design involving a one-off intensive live-in educational workshop on lifestyle modification for people with MS. We aimed to examine changes in a range of clinical and lifestyle variables and quality of life, self-efficacy, physical impact of MS and disability from baseline to 3- and 5-years post-intervention.
95 participants completed the baseline survey. Data included lifestyle risk factors of diet quality, meat and dairy consumption, omega 3 and vitamin D supplementation, physical activity, stress reducing activities, and smoking status, and use of disease-modifying therapies (DMTs). Patient-reported outcomes included health-related quality of life, self-efficacy, physical impact of MS and disability. Generalised estimating equation models were used to account for within-participant correlation over time.
Sixty participants (63.2%) provided data at 3- and 5-years. Significant improvements in diet quality, omega 3 supplementation, and non-smoking were seen at both timepoints. Use of DMTs and disability remained unchanged. Mental (8.8- and 6.9-point) and physical (10.5- and 7.3-point) quality of life, and self-efficacy (2.4- and 1.9-point) improved significantly at 3- and 5-years, respectively. Physical impact of MS reduced from baseline to 3-years (-3.7 points) with a trend towards reduction at 5-years (-2.9 points; p = 0.079).
Education on lifestyle modification can lead to lifestyle modification and short and long-term improvements in mental and physical wellbeing outcomes. Results suggest potential value in lifestyle modification as an adjunctive component to standard therapy for MS.
可改变的生活方式风险因素对多发性硬化症（MS）进展的影响已得到越来越多的研究。本研究采用单组设计，为MS患者举办了一次关于生活方式改变的一次性强化住校教育研讨会。我们旨在研究一系列临床和生活方式变量、生活质量、自我效能感、MS的身体影响以及残疾程度从基线到干预后3年和5年的变化。
95名参与者完成了基线调查。数据包括饮食质量、肉类和奶制品消费、ω-3和维生素D补充剂、身体活动、减压活动和吸烟状况等生活方式风险因素，以及疾病修正疗法（DMTs）的使用情况。患者报告的结果包括与健康相关的生活质量、自我效能感、MS的身体影响和残疾程度。使用广义估计方程模型来考虑参与者随时间的相关性。
60名参与者（63.2%）在3年和5年时提供了数据。在两个时间点，饮食质量、ω-3补充剂的使用和戒烟方面均有显著改善。DMTs的使用和残疾程度保持不变。精神生活质量（分别提高8.8分和6.9分）和身体生活质量（分别提高10.5分和7.3分）以及自我效能感（分别提高2.4分和1.9分）在3年和5年时分别有显著改善。MS的身体影响从基线到3年有所降低（-3.7分），在5年时有降低趋势（-2.9分；p = 0.079）。
关于生活方式改变的教育可促进生活方式的改变，并在短期和长期内改善身心健康结果。结果表明，生活方式改变作为MS标准治疗的辅助组成部分具有潜在价值。
