Törnebrandt K, Eskilsson J, Nobin A
Clin Cardiol. 1986 Jan;9(1):13-9. doi: 10.1002/clc.4960090104.
Sixteen patients with metastatic carcinoid tumors of ileal or cecal origin were studied in order to evaluate the frequency and degree of cardiac involvement in a nonselected patient group. We have also studied the correlation between plasma hormone levels (e.g., 5-hydroxytryptamine (5-HT) and substance P) and the degree of cardiac involvement. The patients underwent physical examinations, electrocardiograms, chest x-rays, cardiac catheterization, and echocardiography. Plasma levels of 5-HT and substance P were analyzed. Carcinoid heart involvement was found in 3 of 16 patients (19%) but no patient had subjective symptoms associated with heart disease. Four patients (25%) had slight pulmonary hypertension. No left-sided heart lesions were seen. No correlation between blood levels of 5-HT or substance P and heart involvement was found. Eight patients died during the follow-up period, but in none of these was the cause of death cardiac failure. Carcinoid heart disease is not as common in our patients as in patients selected on a cardiological basis described in earlier studies. Echocardiography appears to be the most efficient technique for detection of even subclinical heart involvement and a useful tool for following its progress.
为评估非选择性患者群体中心脏受累的频率和程度，对16例回肠或盲肠起源的转移性类癌肿瘤患者进行了研究。我们还研究了血浆激素水平（如5-羟色胺（5-HT）和P物质）与心脏受累程度之间的相关性。患者接受了体格检查、心电图、胸部X光、心导管检查和超声心动图检查。分析了5-HT和P物质的血浆水平。16例患者中有3例（19%）发现类癌心脏受累，但无患者有与心脏病相关的主观症状。4例患者（25%）有轻度肺动脉高压。未发现左侧心脏病变。未发现5-HT或P物质的血水平与心脏受累之间存在相关性。8例患者在随访期间死亡，但均非死于心力衰竭。类癌心脏病在我们的患者中不如早期研究中基于心脏病学选择的患者中常见。超声心动图似乎是检测甚至亚临床心脏受累的最有效技术，也是跟踪其进展的有用工具。
