Akhter Tansim, Hedeland Mikael, Bergquist Jonas, Larsson Anders, Axelsson Ove, Hesselman Susanne, Skalkidou Alkistis
Department of Women's and Children's Health, Section of Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden.
Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden.
Am J Hypertens. 2025 Feb 18;38(3):184-191. doi: 10.1093/ajh/hpae131.
Preeclampsia is associated with higher levels of asymmetric (ADMA) and symmetric (SDMA) dimethylarginines. Dimethylarginines are inhibitors of nitric oxide, a uterine smooth muscles relaxant. Women with preeclampsia experience a shorter labor duration compared with normotensive women. However, very little is known about the possible biochemical mechanisms behind these differences. We aimed to investigate if women with preeclampsia had higher levels of arginines (ADMA, SDMA, and l-arginine) at labor than controls and also investigate the association between arginines and labor duration.
The study was based on data from the Swedish, Uppsala County population-based, prospective cohort BASIC, 2009-2018. Arginines were analyzed by ultra-high-performance liquid chromatography using plasma samples taken at labor from women with preeclampsia (n = 47) and normotensive pregnancy (n = 90). We also analyzed inflammation markers such as C-reactive protein, tumor necrosis factor (TNF)-R1, TNF-R2, and growth differentiation factor (GDF-15).
Women with preeclampsia had higher levels of ADMA (P < 0.001), SDMA (P < 0.001), l-arginine (P < 0.001), TNF-R1 (P < 0.001), TNF-R2 (P = 0.03), and GDF-15 (P < 0.01) compared with controls. Furthermore, ADMA and SDMA, not inflammation markers, were negatively correlated to labor duration in preeclampsia. No correlations were observed when comparing arginines and inflammation markers.
Among women with preeclampsia, our novel findings of higher level of arginines, negative correlation of arginines to labor duration, and absence of correlation of arginines to inflammation markers might support the theory that it is not inflammation but arginines which could be associated with shorter labor duration in preeclampsia.
子痫前期与较高水平的不对称二甲基精氨酸（ADMA）和对称二甲基精氨酸（SDMA）有关。二甲基精氨酸是一氧化氮的抑制剂，而一氧化氮是一种子宫平滑肌松弛剂。与血压正常的女性相比，子痫前期女性的产程较短。然而，对于这些差异背后可能的生化机制知之甚少。我们旨在研究子痫前期女性在分娩时的精氨酸（ADMA、SDMA和L-精氨酸）水平是否高于对照组，并研究精氨酸与产程之间的关联。
该研究基于2009年至2018年瑞典乌普萨拉县基于人群的前瞻性队列BASIC的数据。使用子痫前期女性（n = 47）和血压正常孕妇（n = 90）分娩时采集的血浆样本，通过超高效液相色谱法分析精氨酸。我们还分析了炎症标志物，如C反应蛋白、肿瘤坏死因子（TNF）-R1、TNF-R2和生长分化因子（GDF-15）。
与对照组相比，子痫前期女性的ADMA（P < 0.001）、SDMA（P < 0.001）、L-精氨酸（P < 0.001）、TNF-R1（P < 0.001）、TNF-R2（P = 0.03）和GDF-15（P < 0.01）水平更高。此外，在子痫前期中，ADMA和SDMA而非炎症标志物与产程呈负相关。比较精氨酸和炎症标志物时未观察到相关性。
在子痫前期女性中，我们关于精氨酸水平较高、精氨酸与产程呈负相关以及精氨酸与炎症标志物无相关性的新发现可能支持这样一种理论，即子痫前期产程较短可能与精氨酸有关，而非炎症。
