Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Centre for Reproductive Biology in Uppsala (CRU), Uppsala University, Uppsala, Sweden.
BMJ Open. 2019 Oct 22;9(10):e031514. doi: 10.1136/bmjopen-2019-031514.
With the population-based, prospective Biology, Affect, Stress, Imaging and Cognition (BASIC) cohort, we aim to investigate the biopsychosocial aetiological processes involved in perinatal depression (PND) and to pinpoint its predictors in order to improve early detection.
From September 2009 to November 2018, the BASIC study at Uppsala University Hospital, Sweden, has enrolled 5492 women, in 6478 pregnancies, of which 46.3% first-time pregnancies and with an average age of 31.5 years. After inclusion around gestational week 16-18, participants are followed-up with data collection points around gestational week 32, at childbirth, as well as three times postpartum: after 6 weeks, 6 months and 1 year. At the last follow-up, 70.8% still remain in the cohort.
In addition to internet-based surveys with self-report instruments, participants contribute with biological samples, for example, blood samples (maternal and from umbilical cord), biopsies (umbilical cord and placenta) and microbiota samples. A nested case-control subsample also takes part in cognitive and emotional tests, heart rate variability tests and bioimpedance tests. Subprojects have identified various correlates of PND of psychological and obstetric origin in addition to factors of the hypothalamic-pituitary-adrenal axis and immune system.
In parallel with the completion of data collection (final follow-up November 2019), BASIC study data are currently analysed in multiple subprojects. Since 2012, we are conducting an ongoing follow-up study on the participants and their children up to 6 years of age (U-BIRTH). Researchers interested in collaboration may contact Professor Alkistis Skalkidou (corresponding author) with their request to be considered by the BASIC study steering committee.
通过基于人群的前瞻性生物学、情感、应激、影像和认知（BASIC）队列研究，我们旨在探讨围产期抑郁症（PND）相关的生物心理社会病因学过程，并确定其预测因素，以便改善早期发现。
自 2009 年 9 月至 2018 年 11 月，瑞典乌普萨拉大学医院的 BASIC 研究共招募了 5492 名女性，涉及 6478 次妊娠，其中 46.3%为首次妊娠，平均年龄为 31.5 岁。纳入研究时孕周约为 16-18 周，参与者随后在孕周 32 周、分娩时以及产后 6 周、6 个月和 1 年进行 3 次随访。截至最后一次随访，仍有 70.8%的参与者留在队列中。
除了基于互联网的自我报告工具调查外，参与者还提供了生物样本，例如血样（母亲和脐血）、活检（脐带和胎盘）和微生物组样本。一个嵌套的病例对照子样本也参与了认知和情绪测试、心率变异性测试和生物阻抗测试。子项目确定了除下丘脑-垂体-肾上腺轴和免疫系统因素外，PND 的心理和产科起源的各种相关因素。
在完成数据收集（最终随访日期为 2019 年 11 月）的同时，BASIC 研究数据目前正在多个子项目中进行分析。自 2012 年以来，我们一直在对参与者及其儿童进行一项正在进行的随访研究，直至 6 岁（U-BIRTH）。有合作意向的研究人员可以与 Alkistis Skalkidou 教授（通讯作者）联系，提出申请，由 BASIC 研究指导委员会进行审议。
