Adam Tugdual, Barateau Lucie, Tanty Jérôme, Dauvilliers Yves
Institute of Neurosciences of Montpellier (INM), University of Montpellier, INSERM, Montpellier, France.
Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, Montpellier, France.
Sleep. 2025 Mar 11;48(3). doi: 10.1093/sleep/zsae246.
To investigate the amplitude and phase of the circadian rhythm of core body temperature (CBT) via the continuous measure of the gastrointestinal temperature in participants with idiopathic hypersomnia (IH), non-specified hypersomnia (NSH) compared to healthy controls (HC) in a constant routine standardized bedrest (BR) protocol.
Consecutive participants evaluated in a National Reference Center for Rare Hypersomnias benefited from an extensive evaluation with one-night polysomnography, followed by a modified Multiple Sleep Latency Test (mMSLT), and a continuous 32-hour BR recording in standardized conditions. CBT was recorded via a telemetry pill (e-Celsius) during the BR, modeled by a Cosinor, with extraction of MESOR, amplitude, and phase. Participants with IH, diagnosed according to the International Classification of Sleep Disorders-3, were compared with participants with NSH (complaint of hypersomnolence but normal mMSLT and BR), and HC. Participants were divided into four groups based on their mMSLT mean sleep latency (mMSLT+,≤8 minutes) and their BR total sleep time (BR+, ≥19 hours).
A total of 108 participants (80% women, 28.3 ± 7.8 years old) were included in the analyses, 81 IH (83% women), 16 NSH (75% women), and 11 HC (64% women). Cosinor amplitude and phase of CBT did not differ between IH, NSH, and HC, nor in the subgroup analysis (37 BR+/mMSLT+, 35 BR+/mMSLT-, 9 BR-/mMSLT+, 27 BR-/mMSLT-). No difference in chronotypes was observed between groups. Women had a greater MESOR and reduced CBT amplitude compared to men.
The circadian rhythm of CBT showed no difference in amplitude or phase between IH, NSH, and HC, and was not related to prolonged sleep time or objective daytime sleepiness.
通过在持续常规标准化卧床休息（BR）方案中，对特发性嗜睡症（IH）、未特定的嗜睡症（NSH）参与者以及健康对照（HC）的胃肠道温度进行连续测量，来研究核心体温（CBT）昼夜节律的幅度和相位。
在国家罕见嗜睡症参考中心接受评估的连续参与者，受益于一项广泛评估，包括一晚多导睡眠图检查，随后进行改良多次睡眠潜伏期试验（mMSLT），以及在标准化条件下进行连续32小时的BR记录。在BR期间，通过遥测药丸（e-Celsius）记录CBT，采用余弦分析法，提取中值（MESOR）、幅度和相位。根据《国际睡眠障碍分类第3版》诊断为IH的参与者，与NSH参与者（有嗜睡主诉但mMSLT和BR正常）以及HC进行比较。参与者根据其mMSLT平均睡眠潜伏期（mMSLT+，≤8分钟）和BR总睡眠时间（BR+，≥19小时）分为四组。
共有108名参与者（80%为女性，年龄28.3±7.8岁）纳入分析，其中81名IH患者（83%为女性），16名NSH患者（75%为女性），11名HC（64%为女性）。IH、NSH和HC之间，以及亚组分析（37名BR+/mMSLT+、35名BR+/mMSLT-、9名BR-/mMSLT+、27名BR-/mMSLT-）中，CBT的余弦分析幅度和相位均无差异。各组之间未观察到昼夜节律类型的差异。与男性相比，女性的中值更大，CBT幅度更小。
CBT的昼夜节律在IH、NSH和HC之间，在幅度或相位上均无差异，且与延长的睡眠时间或客观的日间嗜睡无关。
