Sangal R B, Sangal J M
Wayne State University School of Medicine, Troy, Michigan, USA.
Clin Electroencephalogr. 1995 Jul;26(3):146-53. doi: 10.1177/155005949502600305.
To evaluate cognitive abnormalities in excessive daytime sleepiness (EDS) using cognitive evoked potentials (P300), and to evaluate if P300 measures differentiate among disorders of EDS, a series of EDS subjects were administered a polysomnogram, auditory and visual P300 testing using 31 scalp electrodes, and a multiple sleep latency test. P300 variables were compared with those of normal subjects. Forty normal subjects ages 16 to 65 years, and 69 EDS patients ages 16 to 65 years were used. Of these, 39 had profound obstructive sleep apnea (OSA, Respiratory Disturbance Index or RDI > 80/h sleep) with severe somnolence (Mean Sleep Latency < 5 min). Twenty-two had idiopathic hypersomnia (IH). Eight had narcolepsy. The normals and the three EDS groups did not differ in age. IH and profound OSA patients had longer visual P300 latency than normals or narcolepsy patients (p < 0.05). (p < 0.05). IH and profound OSA patients had longer auditory P300 latency than normals. They had smaller auditory P300 amplitude than narcolepsy patients. There were visual P300 latency topographic differences between normals and profound OSA patients. In conclusion, IH and profound OSA patients show cognitive evoked potential evidence of cognitive dysfunction. Narcolepsy patients do not show such evidence. Visual P300 latency differentiates among disorders of EDS.
为了使用认知诱发电位（P300）评估日间过度嗜睡（EDS）中的认知异常，并评估P300测量是否能区分EDS的不同疾病，对一系列EDS受试者进行了多导睡眠图检查、使用31个头皮电极进行听觉和视觉P300测试以及多次睡眠潜伏期测试。将P300变量与正常受试者的变量进行比较。使用了40名年龄在16至65岁之间的正常受试者和69名年龄在16至65岁之间的EDS患者。其中，39例患有严重阻塞性睡眠呼吸暂停（OSA，呼吸紊乱指数或RDI>80次/小时睡眠）且伴有严重嗜睡（平均睡眠潜伏期<5分钟）。22例患有特发性嗜睡症（IH）。8例患有发作性睡病。正常组和三个EDS组在年龄上没有差异。IH和严重OSA患者的视觉P300潜伏期比正常组或发作性睡病患者更长（p<0.05）。（p<0.05）。IH和严重OSA患者的听觉P300潜伏期比正常组更长。他们的听觉P300波幅比发作性睡病患者更小。正常组和严重OSA患者之间存在视觉P300潜伏期的地形图差异。总之，IH和严重OSA患者显示出认知功能障碍的认知诱发电位证据。发作性睡病患者没有显示出这样的证据。视觉P300潜伏期可区分EDS的不同疾病。
