头孢匹胺（SM-1652）对革兰氏阴性杆菌的体外活性。

In vitro activity of cefpiramide (SM-1652) against gram-negative bacilli.

作者信息

Fass R J, Helsel V L

出版信息

Diagn Microbiol Infect Dis. 1986 Jan;4(1):77-81. doi: 10.1016/0732-8893(86)90060-x.

Abstract

The susceptibilities of 317 gram-negative bacilli to cefpiramide, cefotaxime, and piperacillin were determined by standardized microdilution and disk diffusion tests. Cefpiramide and piperacillin were more consistently active against nonfermenters than against Enterobacteriaceae, whereas cefotaxime was more active against Enterobacteriaceae. Inhibitory zone diameters of approximately 75-micrograms cefpiramide disks correlated well with minimal inhibitory concentrations (r = 0.85); breakpoints for defining susceptibility and resistance were recommended.

摘要

通过标准化微量稀释法和纸片扩散试验测定了317株革兰氏阴性杆菌对头孢匹胺、头孢噻肟和哌拉西林的敏感性。头孢匹胺和哌拉西林对非发酵菌的活性比对肠杆菌科细菌更稳定，而头孢噻肟对肠杆菌科细菌的活性更强。约75微克头孢匹胺纸片的抑菌圈直径与最低抑菌浓度相关性良好（r = 0.85）；推荐了定义敏感和耐药的断点。