Abraham E, Chang Y H
Crit Care Med. 1986 Feb;14(2):81-6. doi: 10.1097/00003246-198602000-00001.
Bacterial infection often occurs after trauma and hemorrhage and is believed to be a reflection of a compromised host defense system. In the present study, the effect of hemorrhage on phytohemagglutinin-induced lymphocyte proliferation was investigated. Lymphocytes obtained from rats 2 h after blood withdrawal in an amount equivalent to 30% of total blood volume showed a 48% reduction in proliferative response as compared to cells obtained from the same animal before bleeding. This depression in lymphocyte proliferative capacity appeared to be due to a serum factor or factors induced by hemorrhage. The hemorrhage-induced serum factor(s) is heat-stable, dialyzable, and has an apparent molecular weight between 13,000 and 23,000 on gel filtration chromatography. The hemorrhage-induced factor seems to suppress lymphocyte proliferation in a rapid and irreversible manner. This abnormality in host defense mechanisms may contribute to the increased incidence of sepsis present after trauma and hemorrhage.
细菌感染常在创伤和出血后发生，被认为是宿主防御系统受损的一种表现。在本研究中，研究了出血对植物血凝素诱导的淋巴细胞增殖的影响。从失血相当于总血量30%的大鼠身上在失血2小时后获取的淋巴细胞，与同一动物出血前获取的细胞相比，增殖反应降低了48%。淋巴细胞增殖能力的这种降低似乎是由于出血诱导的一种或多种血清因子所致。出血诱导的血清因子是热稳定的、可透析的，在凝胶过滤色谱上其表观分子量在13,000至23,000之间。出血诱导的因子似乎以快速且不可逆的方式抑制淋巴细胞增殖。宿主防御机制的这种异常可能导致创伤和出血后败血症发病率的增加。
