通过出血和出血血清产生功能活跃的抑制细胞。
Generation of functionally active suppressor cells by haemorrhage and haemorrhagic serum.
作者信息
Abraham E, Chang Y H
机构信息
Department of Medicine, UCLA Medical Center 90024.
出版信息
Clin Exp Immunol. 1988 May;72(2):238-42.
Mitogen (PHA)-induced proliferation of peripheral blood mononuclear cells (PBMC) was reduced by more than 70% 2 h after the haemorrhage of 30% of blood volume. Experiments using isolated macrophages and lymphocytes showed that post-haemorrhage macrophages were functionally normal and that lymphocytes were responsible for the observed haemorrhage-induced depression of proliferative response. Surface marker determinations showed that at least some, if not all, of the haemorrhage-induced suppressor cells are of the OX8+ phenotype. Exposure of PBMCs to serum from bled animals also brought about activation of OX8+ suppressor T cells. These results suggest that the depressed proliferative response of PBMCs induced by haemorrhage or by exposing the cells to haemorrhagic serum (serum from bled animals) is due to the activation of OX8+ suppressor T cells.
在失血30%血容量后2小时，丝裂原（PHA）诱导的外周血单个核细胞（PBMC）增殖减少了70%以上。使用分离的巨噬细胞和淋巴细胞进行的实验表明，出血后巨噬细胞功能正常，淋巴细胞是观察到的出血诱导的增殖反应抑制的原因。表面标志物测定表明，至少部分（如果不是全部）出血诱导的抑制细胞具有OX8 + 表型。将PBMC暴露于失血动物的血清也会导致OX8 + 抑制性T细胞的激活。这些结果表明，出血或使细胞暴露于出血血清（失血动物的血清）诱导的PBMC增殖反应降低是由于OX8 + 抑制性T细胞的激活。
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