诱导型 TGFβ2 眼高压小鼠模型。
The Inducible TGFβ2 Ocular Hypertension Mouse Model.
机构信息
Department of Ophthalmology, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
Methods Mol Biol. 2025;2858:123-129. doi: 10.1007/978-1-0716-4140-8_11.
There is a great need for the development of mouse models of ocular hypertension. Here, we describe an inducible mouse model of ocular hypertension that produces a homogeneous intraocular pressure (IOP) response and can be induced in any mouse strain of choice without the need for extensive breeding. The procedure utilizes an ocular hypertension and glaucoma-relevant transgene, bioactivated TGFβ2, and an adenovirus 5 virus with select tropism for the trabecular meshwork (TM).
非常需要开发眼高压的小鼠模型。在这里，我们描述了一种可诱导的眼高压小鼠模型，该模型可产生均匀的眼内压（IOP）反应，并且无需广泛繁殖即可在任何所需的小鼠品系中诱导产生。该方法利用了与眼高压和青光眼相关的转基因、生物激活的 TGFβ2 和一种对小梁网（TM）具有选择性趋向性的腺病毒 5 病毒。
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