Balshi Alexandra, Dempsey John, Sloane Jacob A
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Kirstein 215, Boston, MA, 02215, USA.
J Neurovirol. 2024 Dec;30(5-6):556-558. doi: 10.1007/s13365-024-01230-x. Epub 2024 Oct 21.
We report two patients who developed atypical, disseminated herpes zoster infections while on dimethyl fumarate (DMF) treatment, one with varicella zoster virus (VZV) encephalitis and another with herpes zoster oticus resulting in lasting motor and sensory deficits. We recommend vaccination against VZV prior to DMF initiation be incorporated as standard of care, as ensuring patients are protected against VZV before starting DMF can prevent such severe outcomes.
我们报告了两名在接受富马酸二甲酯（DMF）治疗期间发生非典型播散性带状疱疹感染的患者，其中一名患有水痘带状疱疹病毒（VZV）脑炎，另一名患有耳带状疱疹，导致持续的运动和感觉功能障碍。我们建议在开始使用DMF之前接种VZV疫苗应作为标准治疗措施，因为在开始使用DMF之前确保患者免受VZV感染可以预防此类严重后果。
