Dempsey John, Balshi Alexandra, Sloane Jacob
SUNY Upstate Medical University Norton College of Medicine, Syracuse, New York, USA
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
BMJ Case Rep. 2025 Apr 2;18(4):e264081. doi: 10.1136/bcr-2024-264081.
We present a case of a woman in her 50s with relapsing-remitting multiple sclerosis, treated with diroximel fumarate, who developed an itching, burning vesicular rash following a C3 dermatomal distribution on her left face and neck. She was diagnosed with herpes zoster, treated with valacyclovir and gabapentin, and made a full recovery. Ensuring patients are protected against varicella-zoster virus before starting diroximel fumarate can prevent this painful infection. Thus, we recommend vaccination against the varicella-zoster virus prior to diroximel fumarate initiation be incorporated as the standard of care.
我们报告一例50多岁复发性缓解型多发性硬化症女性患者，她正在接受富马酸二甲酯治疗，之后在左侧面部和颈部出现沿C3皮节分布的瘙痒性、灼痛性水疱皮疹。她被诊断为带状疱疹，接受了伐昔洛韦和加巴喷丁治疗，并完全康复。在开始使用富马酸二甲酯之前确保患者免受水痘-带状疱疹病毒感染可预防这种疼痛性感染。因此，我们建议将在开始使用富马酸二甲酯之前接种水痘-带状疱疹病毒疫苗纳入标准治疗方案。
