Gill Sumeen Kaur, Gomer Richard H
Department of Biology, Texas A&M University, College Station, TX 77843, USA.
Cells. 2025 Apr 3;14(7):536. doi: 10.3390/cells14070536.
Fibrosing disorders including idiopathic pulmonary fibrosis (IPF) are progressive irreversible diseases, often with poor prognoses, characterized by the accumulation of excessive scar tissue and extracellular matrix. Translational regulation has emerged as a critical aspect of gene expression control, and the dysregulation of key effectors is associated with disease pathogenesis. This review examines the current literature on translational regulators in IPF, focusing on microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and RNA transcript modifications including alternative polyadenylation and chemical modification. Some of these translational regulators potentiate fibrosis, and some of the regulators inhibit fibrosis. In IPF, some of the profibrotic regulators are upregulated, and some of the antifibrotic regulators are downregulated. Correcting these defects in IPF-associated translational regulators could be an intriguing avenue for therapeutics.
包括特发性肺纤维化（IPF）在内的纤维化疾病是进行性不可逆疾病，通常预后较差，其特征是过度瘢痕组织和细胞外基质的积累。翻译调控已成为基因表达控制的一个关键方面，关键效应器的失调与疾病发病机制相关。本综述研究了目前关于IPF中翻译调节因子的文献，重点关注微小RNA（miRNA）、长链非编码RNA（lncRNA）以及包括可变聚腺苷酸化和化学修饰在内的RNA转录修饰。这些翻译调节因子中的一些促进纤维化，而一些则抑制纤维化。在IPF中，一些促纤维化调节因子上调，一些抗纤维化调节因子下调。纠正IPF相关翻译调节因子中的这些缺陷可能是一个有趣的治疗途径。
