The NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, London, United Kingdom.
Centre for Antimicrobial Optimisation, Imperial College London, London, United Kingdom.
Nat Commun. 2024 Oct 21;15(1):9070. doi: 10.1038/s41467-024-53192-7.
Beta-lactamase-producing Enterobacteriaceae present a significant therapeutic challenge. Current developments in phenotypic diagnostics focus primarily on rapid minimum inhibitory concentration (MIC) determination. There is a requirement for rapid phenotypic diagnostics to improve antimicrobial susceptibility tests (AST) and aid prescribing decisions. Phenotypic AST are limited in their ability to characterise beta-lactamase-producing Enterobacteriaceae in detail. Despite advances in rapid AST, gaps and opportunities remain for developing additional diagnostic approaches that facilitate personalised antimicrobial prescribing. In this perspective, we highlight the state-of-the-art in beta-lactamase detection, identify gaps in current practice, and discuss barriers for innovation within this field.
产β-内酰胺酶的肠杆菌科是一个重大的治疗挑战。目前表型诊断学的发展主要集中在快速最小抑菌浓度（MIC）的测定上。需要快速表型诊断来改善抗菌药物敏感性测试（AST）并辅助处方决策。表型 AST 在详细描述产β-内酰胺酶的肠杆菌科方面能力有限。尽管快速 AST 取得了进展，但在开发有助于个体化抗菌药物处方的其他诊断方法方面仍存在差距和机会。在这个角度下，我们强调了β-内酰胺酶检测的最新技术，确定了当前实践中的差距，并讨论了该领域创新的障碍。
