From the *Department of Pathology, Stanford University School of Medicine, Stanford; †Clinical Microbiology Laboratory, Stanford University Medical Center, Palo Alto; ‡Department of Pediatrics, Stanford University School of Medicine, Stanford; §Cepheid, Sunnyvale; and ¶Department of Medicine, Stanford University School of Medicine, Stanford, CA.
Pediatr Infect Dis J. 2013 Nov;32(11):1291-4. doi: 10.1097/INF.0b013e31829eca34.
We report the second pediatric case of New Delhi metallo-β-lactamase-1-producing Enterobacteriaceae in the United States. Laboratory methods included various phenotypic antimicrobial susceptibility testing assays, as well as polymerase chain reaction assays for carbapenemase-encoding genes. Laboratory challenges and the limited number of effective antimicrobial agents and the lack of pediatric-specific safety and efficacy data for these drugs are discussed.
我们报告了美国第二例新德里金属β-内酰胺酶 1 产肠杆菌科的儿科病例。实验室方法包括各种表型抗菌药物敏感性检测试验，以及针对碳青霉烯酶编码基因的聚合酶链反应检测试验。讨论了实验室面临的挑战，以及有限数量的有效抗菌药物，以及这些药物缺乏儿科专用的安全性和疗效数据。
