• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

心脏代谢疾病中的细胞衰老

Cell senescence in cardiometabolic diseases.

作者信息

Grootaert Mandy O J

机构信息

Endocrinology, Diabetes and Nutrition, UCLouvain, Brussels, Belgium.

Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.

出版信息

NPJ Aging. 2024 Oct 21;10(1):46. doi: 10.1038/s41514-024-00170-4.

DOI:10.1038/s41514-024-00170-4
PMID:39433786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11493982/
Abstract

Cellular senescence has been implicated in many age-related pathologies including atherosclerosis, heart failure, age-related cardiac remodeling, diabetic cardiomyopathy and the metabolic syndrome. Here, we will review the characteristics of senescent cells and their endogenous regulators, and summarize the metabolic stressors that induce cell senescence. We will discuss the evidence of cell senescence in the onset and progression of several cardiometabolic diseases and the therapeutic potential of anti-senescence therapies.

摘要

细胞衰老与许多与年龄相关的病理状况有关，包括动脉粥样硬化、心力衰竭、与年龄相关的心脏重塑、糖尿病性心肌病和代谢综合征。在此，我们将综述衰老细胞的特征及其内源性调节因子，并总结诱导细胞衰老的代谢应激源。我们将讨论细胞衰老在几种心脏代谢疾病的发生和发展中的证据以及抗衰老疗法的治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af86/11493982/aa1311dac748/41514_2024_170_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af86/11493982/6bf434c0bf44/41514_2024_170_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af86/11493982/7f5581a75e69/41514_2024_170_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af86/11493982/aa1311dac748/41514_2024_170_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af86/11493982/6bf434c0bf44/41514_2024_170_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af86/11493982/7f5581a75e69/41514_2024_170_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af86/11493982/aa1311dac748/41514_2024_170_Fig3_HTML.jpg

相似文献

1
Cell senescence in cardiometabolic diseases.心脏代谢疾病中的细胞衰老
NPJ Aging. 2024 Oct 21;10(1):46. doi: 10.1038/s41514-024-00170-4.
2
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease.靶向心脏干细胞衰老治疗心脏衰老和疾病。
Cells. 2020 Jun 26;9(6):1558. doi: 10.3390/cells9061558.
3
The role of cellular senescence in cardiac disease: basic biology and clinical relevance.细胞衰老在心脏疾病中的作用：基础生物学与临床相关性。
Nat Rev Cardiol. 2022 Apr;19(4):250-264. doi: 10.1038/s41569-021-00624-2. Epub 2021 Oct 19.
4
Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease.细胞衰老影响缺血性心脏病中的心脏再生与修复。
Aging Dis. 2021 Apr 1;12(2):552-569. doi: 10.14336/AD.2020.0811. eCollection 2021 Apr.
5
Senescence mechanisms and targets in the heart.心脏衰老的机制和靶点。
Cardiovasc Res. 2022 Mar 25;118(5):1173-1187. doi: 10.1093/cvr/cvab161.
6
Cellular senescence in cardiac diseases.心脏疾病中的细胞衰老。
J Cardiol. 2019 Oct;74(4):313-319. doi: 10.1016/j.jjcc.2019.05.002. Epub 2019 Jun 12.
7
Cellular Senescence in Cardiovascular Diseases: A Systematic Review.心血管疾病中的细胞衰老：一项系统综述
Aging Dis. 2022 Feb 1;13(1):103-128. doi: 10.14336/AD.2021.0927. eCollection 2022 Feb.
8
Vascular Senescence in Cardiovascular and Metabolic Diseases.心血管和代谢疾病中的血管衰老
Front Cardiovasc Med. 2018 Mar 5;5:18. doi: 10.3389/fcvm.2018.00018. eCollection 2018.
9
Cellular Senescence in the Lung: The Central Role of Senescent Epithelial Cells.肺部细胞衰老：衰老上皮细胞的核心作用。
Int J Mol Sci. 2020 May 6;21(9):3279. doi: 10.3390/ijms21093279.
10
m A methylation in cellular senescence of age-associated diseases.m A 甲基化在与年龄相关的疾病的细胞衰老中。
Acta Biochim Biophys Sin (Shanghai). 2023 Jul 3;55(8):1168-1183. doi: 10.3724/abbs.2023107.

引用本文的文献

1
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging.衰老过程中，肠道微生物群依赖的苯乙酸增加会诱导内皮细胞衰老。
Nat Aging. 2025 May 12. doi: 10.1038/s43587-025-00864-8.
2
Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?衰老细胞清除疗法用于心血管疾病是否已准备好转化至临床应用？
Biomolecules. 2025 Apr 8;15(4):545. doi: 10.3390/biom15040545.

本文引用的文献

1
The senescence-associated secretory phenotype and its physiological and pathological implications.衰老相关的分泌表型及其生理和病理意义。
Nat Rev Mol Cell Biol. 2024 Dec;25(12):958-978. doi: 10.1038/s41580-024-00727-x. Epub 2024 Apr 23.
2
Targeting aging and age-related diseases with vaccines.用疫苗靶向衰老和与年龄相关的疾病。
Nat Aging. 2024 Apr;4(4):464-482. doi: 10.1038/s43587-024-00597-0. Epub 2024 Apr 15.
3
Palmitic acid in type 2 diabetes mellitus promotes atherosclerotic plaque vulnerability via macrophage Dll4 signaling.
棕榈酸在 2 型糖尿病中通过巨噬细胞 Dll4 信号促进动脉粥样硬化斑块易损性。
Nat Commun. 2024 Feb 12;15(1):1281. doi: 10.1038/s41467-024-45582-8.
4
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction.衰老细胞清除型嵌合抗原受体 T 细胞对与年龄相关的代谢功能障碍的预防和长效疗效。
Nat Aging. 2024 Mar;4(3):336-349. doi: 10.1038/s43587-023-00560-5. Epub 2024 Jan 24.
5
Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality.用 ABT-263 治疗晚期动脉粥样硬化小鼠可降低斑块稳定性指标并增加死亡率。
JCI Insight. 2024 Jan 23;9(2):e173863. doi: 10.1172/jci.insight.173863.
6
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.间歇性补充非瑟酮可通过减少细胞衰老来改善老年小鼠的动脉功能。
Aging Cell. 2024 Mar;23(3):e14060. doi: 10.1111/acel.14060. Epub 2023 Dec 7.
7
CD38 Deficiency Alleviates Diabetic Cardiomyopathy by Coordinately Inhibiting Pyroptosis and Apoptosis.CD38 缺乏通过协调抑制细胞焦亡和细胞凋亡减轻糖尿病心肌病。
Int J Mol Sci. 2023 Nov 6;24(21):16008. doi: 10.3390/ijms242116008.
8
Meta-Inflammation and New Anti-Diabetic Drugs: A New Chance to Knock Down Residual Cardiovascular Risk.代谢性炎症与新型抗糖尿病药物：降低残余心血管风险的新契机。
Int J Mol Sci. 2023 May 12;24(10):8643. doi: 10.3390/ijms24108643.
9
Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells.二甲双胍可减轻阿霉素诱导的衰老内皮细胞中的衰老相关分泌表型（SASP）分泌以及脂多糖触发的过度炎症反应。
Front Aging. 2023 Apr 24;4:1170434. doi: 10.3389/fragi.2023.1170434. eCollection 2023.
10
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice.在体内进行部分重编程可改变小鼠生理衰老过程中与年龄相关的分子变化。
Nat Aging. 2022 Mar;2(3):243-253. doi: 10.1038/s43587-022-00183-2. Epub 2022 Mar 7.