Okafor K C, Griffin C, Ngole P M
Drug Intell Clin Pharm. 1986 Jan;20(1):60-1. doi: 10.1177/106002808602000110.
A case of thrombocytopenic purpura caused by hydrochlorothiazide is reported. A 65-year-old man received hydrochlorothiazide 50 mg/d to control his mild hypertension. Approximately one year after initiation of therapy, the patient developed epistaxis and generalized malaise with anorexia. A peripheral blood smear showed a reduction in platelets. The drug was discontinued; two weeks later the patient's symptoms resolved completely and his platelet count returned to normal. The results of several experiments suggest a mechanism of sensitivity, i.e., an antigen-antibody type of reaction. Hydrochlorothiazide therapy should be stopped if thrombocytopenic purpura develops. If recognized early, the symptoms will resolve spontaneously. The use of corticosteroids may aid in shortening the duration of thrombocytopenia.
报告了1例由氢氯噻嗪引起的血小板减少性紫癜病例。一名65岁男性接受氢氯噻嗪50mg/d以控制轻度高血压。治疗开始约一年后，患者出现鼻出血、全身不适伴厌食。外周血涂片显示血小板减少。停用该药物；两周后患者症状完全缓解，血小板计数恢复正常。几项实验结果提示了一种敏感机制，即抗原-抗体反应类型。如果发生血小板减少性紫癜，应停用氢氯噻嗪治疗。如果早期识别，症状将自发缓解。使用皮质类固醇可能有助于缩短血小板减少的持续时间。
