Hysell J K, Hysell J W, Gray J M
JAMA. 1977 Jan 24;237(4):361-2.
A 48-year-old woman had severe symptomatic thrombocytopenia three times in 13 months. Each episode followed ingestion of iopanoic acid. The interval between drug ingestion and onset of symptoms was 40, 12, and 8 hours. Resolution to normal platelet counts occurred in 6, 5, and 8 days. The third thrombocytopenic crisis occurred while the patient was receiving maintenance steroid therapy, given because the initial diagnosis was idiopathic thrombocytopenic purpura. Incubation of platelet-rich plasma with the patient's serum caused platelet lysis if either the patient or the donor serum obtained after ingestion of iopanoic acid was present in the mixture.
一名48岁女性在13个月内3次出现严重的症状性血小板减少症。每次发作均在摄入碘番酸之后。药物摄入与症状发作之间的间隔分别为40、12和8小时。血小板计数在6、5和8天恢复正常。第三次血小板减少危机发生在患者接受维持性类固醇治疗期间，最初诊断为特发性血小板减少性紫癜而给予该治疗。如果混合物中存在摄入碘番酸后获得的患者血清或供体血清，则富含血小板的血浆与患者血清一起孵育会导致血小板溶解。
