• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

阿莫西林和拉莫三嗪诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状综合征：一例报告。

Amoxicillin and lamotrigine-induced DRESS syndrome: A case report.

作者信息

Demas Nicholas, Shaikh Mohammad Baseem

机构信息

University of Kentucky College of Medicine Lexington Kentucky USA.

Divison of Internal Medicine, University of Kentucky College of Medicine University of Kentucky Lexington Kentucky USA.

出版信息

Clin Case Rep. 2024 Oct 21;12(10):e9487. doi: 10.1002/ccr3.9487. eCollection 2024 Oct.

DOI:10.1002/ccr3.9487
PMID:39434770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11491681/
Abstract

This case demonstrated with importance of recognizing DRESS syndrome presenting without the typical eosinophilia due to possible cross-reactivity between amoxicillin and the well-documented inciting medication lamotrigine. Steroid tapering is an effective treatment, but medication avoidance should be stressed to avoid symptom recurrence.

摘要

该病例表明，认识到由于阿莫西林与已充分记录的诱发药物拉莫三嗪之间可能存在交叉反应，导致药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征在无典型嗜酸性粒细胞增多的情况下出现的重要性。逐渐减少类固醇剂量是一种有效的治疗方法，但应强调避免使用药物以防止症状复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd77/11491681/2cd7f4c0ab2d/CCR3-12-e9487-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd77/11491681/f6139ddddd9d/CCR3-12-e9487-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd77/11491681/fe496e74388f/CCR3-12-e9487-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd77/11491681/b936c2af6a9f/CCR3-12-e9487-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd77/11491681/2cd7f4c0ab2d/CCR3-12-e9487-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd77/11491681/f6139ddddd9d/CCR3-12-e9487-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd77/11491681/fe496e74388f/CCR3-12-e9487-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd77/11491681/b936c2af6a9f/CCR3-12-e9487-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd77/11491681/2cd7f4c0ab2d/CCR3-12-e9487-g001.jpg

相似文献

1
Amoxicillin and lamotrigine-induced DRESS syndrome: A case report.阿莫西林和拉莫三嗪诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状综合征：一例报告。
Clin Case Rep. 2024 Oct 21;12(10):e9487. doi: 10.1002/ccr3.9487. eCollection 2024 Oct.
2
A Case of Amoxicillin-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (Dress) Syndrome Associated With Significant Reactive Hypereosinophilia (HE): A Case Report.阿莫西林诱发的伴有嗜酸性粒细胞增多和全身症状的药物反应（Dress）综合征合并显著反应性嗜酸性粒细胞增多症（HE）1例：病例报告
Cureus. 2023 Jul 10;15(7):e41646. doi: 10.7759/cureus.41646. eCollection 2023 Jul.
3
DRESS is a Mess: A Case of Cross Reactivity Between Lacosamide and Lamotrigine.DRESS 是一种混乱：拉考酰胺和拉莫三嗪交叉反应的病例。
S D Med. 2021 Jul;74(7):324-328.
4
First report of lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome with pancreatitis.首例拉莫三嗪致皮疹伴嗜酸性粒细胞增多和全身症状综合征伴胰腺炎。
Ann Pharmacother. 2010 Dec;44(12):1998-2000. doi: 10.1345/aph.1P350. Epub 2010 Nov 23.
5
Lamotrigine induced DRESS syndrome.拉莫三嗪引起的 DRESS 综合征。
Indian J Pharmacol. 2012 Nov-Dec;44(6):798-800. doi: 10.4103/0253-7613.103305.
6
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries.两则前瞻性药物性肝损伤登记研究中与药物过敏伴嗜酸性粒细胞增多和全身症状相关的药物性肝损伤特征。
Arch Toxicol. 2024 Jan;98(1):303-325. doi: 10.1007/s00204-023-03630-0. Epub 2023 Dec 5.
7
Drug reaction with eosinophilia and systemic symptoms syndrome probably induced by a lamotrigine-ginseng drug interaction.可能由拉莫三嗪与人参药物相互作用引起的伴有嗜酸性粒细胞增多和全身症状的药物反应综合征
Pharmacotherapy. 2015 Mar;35(3):e9-e12. doi: 10.1002/phar.1550. Epub 2015 Mar 10.
8
Dress syndrome and fulminant hepatic failure induced by lamotrigine.拉莫三嗪所致的中毒性表皮坏死松解症和暴发性肝衰竭
Ann Hepatol. 2009 Jan-Mar;8(1):75-7.
9
Cyclosporine as an alternative immunosuppressant for steroid-resistant drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.环孢素作为治疗对类固醇耐药的药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征的替代免疫抑制剂。
BMJ Case Rep. 2023 Mar 21;16(3):e250983. doi: 10.1136/bcr-2022-250983.
10
DRESS induced by amoxicillin-clavulanate in two pediatric patients confirmed by lymphocyte toxicity assay.两名儿科患者中由阿莫西林-克拉维酸引起的药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）通过淋巴细胞毒性试验得以证实。
Allergy Asthma Clin Immunol. 2021 Apr 5;17(1):37. doi: 10.1186/s13223-021-00535-4.

本文引用的文献

1
Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome.拉莫三嗪诱发的药物超敏反应综合征导致的致命性嗜酸性粒细胞性心肌炎和亚大块肝坏死。
Allergy Asthma Clin Immunol. 2023 Oct 25;19(1):92. doi: 10.1186/s13223-023-00848-6.
2
Management and treatment outcome of DRESS patients in Europe: An international multicentre retrospective study of 141 cases.欧洲中毒性表皮坏死松解症伴嗜酸性粒细胞增多和全身症状患者的管理与治疗结果：一项对141例病例的国际多中心回顾性研究。
J Eur Acad Dermatol Venereol. 2023 Apr;37(4):753-762. doi: 10.1111/jdv.18808. Epub 2022 Dec 19.
3
Amoxicillin-clavulanate induced DRESS syndrome masquerading as red man syndrome.
阿莫西林-克拉维酸诱发的药物超敏反应综合征伪装成红人综合征。
J Family Med Prim Care. 2022 Jul;11(7):3992-3995. doi: 10.4103/jfmpc.jfmpc_2073_21. Epub 2022 Jul 22.
4
Drug-Induced Hypersensitivity Syndrome (DIHS)/Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): Clinical Features and Pathogenesis.药物诱导的超敏反应综合征（DIHS）/伴嗜酸性粒细胞增多和全身症状的药物反应（DRESS）：临床特征和发病机制。
J Allergy Clin Immunol Pract. 2022 May;10(5):1155-1167.e5. doi: 10.1016/j.jaip.2022.02.004. Epub 2022 Feb 15.
5
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first-line antituberculosis drugs: Two case reports and a review of the literature.由一线抗结核药物引起的药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征：两例病例报告及文献复习。
Contact Dermatitis. 2019 Nov;81(5):325-331. doi: 10.1111/cod.13296. Epub 2019 May 22.
6
Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): An update in 2019.药物诱导的超敏反应综合征（DiHS）/伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）：2019 年的更新。
Allergol Int. 2019 Jul;68(3):301-308. doi: 10.1016/j.alit.2019.03.006. Epub 2019 Apr 16.
7
Successful treatment of drug reaction with eosinophilia and systemic symptoms syndrome relapse with oral pulsed dexamethasone.口服脉冲地塞米松成功治疗药物反应伴嗜酸性粒细胞增多和全身症状综合征复发。
JAAD Case Rep. 2018 Oct 13;4(9):959-961. doi: 10.1016/j.jdcr.2018.07.015. eCollection 2018 Oct.
8
Lamotrigine induced DIHS/DRESS: Manifestations, treatment, and outcome in 57 patients.拉莫三嗪诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状/药物反应伴嗜酸性粒细胞增多和系统症状：57例患者的表现、治疗及转归
Clin Neurol Neurosurg. 2015 Nov;138:1-7. doi: 10.1016/j.clineuro.2015.07.008. Epub 2015 Jul 8.
9
Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study.药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）：一种原始的多系统药物不良反应。来自前瞻性 RegiSCAR 研究的结果。
Br J Dermatol. 2013 Nov;169(5):1071-80. doi: 10.1111/bjd.12501.
10
DRESS syndrome: Part II. Management and therapeutics.药物反应伴嗜酸性粒细胞增多和全身性症状（DRESS）综合征：第二部分。管理与治疗。
J Am Acad Dermatol. 2013 May;68(5):709.e1-9; quiz 718-20. doi: 10.1016/j.jaad.2013.01.032.