Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
Peking University Health Science Center, Beijing, China.
Front Immunol. 2024 Oct 7;15:1469096. doi: 10.3389/fimmu.2024.1469096. eCollection 2024.
Tumor immunotherapy has been widely used in clinical treatment of various cancers. However, some patients of these cancers do not respond to immunotherapy effectively. And infection has been considered to be related to the efficacy of immunotherapy. This review aims to summarize the different effects and mechanisms of infection on immunotherapy in different kinds of cancers. We searched the relevant literature on and tumor immunotherapy, and summarized to form a review. Generally, infection plays a role in affecting kinds of cancers' development, besides gastric cancer. Current evidence suggests that infection may reduce the efficacy of immunotherapy for colorectal cancer, non-small cell lung cancer and melanoma, but due to the lack of sufficient evidence, more data is needed to prove that. While for gastric cancer, the effects remain controversial. The regulation effects and metabolisms involved in systematic related cancers should be paid attention to. Whether should be eradicated when immunotherapy performed may be a critical consideration for some kinds of tumors.
肿瘤免疫疗法已广泛应用于各种癌症的临床治疗中。然而，这些癌症的一些患者对免疫疗法反应不佳。感染被认为与免疫疗法的疗效有关。本综述旨在总结不同类型的感染对不同类型癌症的免疫治疗的不同影响和作用机制。我们检索了有关感染和肿瘤免疫治疗的相关文献，并进行了总结，形成了一篇综述。一般来说，感染除了胃癌外，还在影响各种癌症的发展。目前的证据表明，感染可能会降低结直肠癌、非小细胞肺癌和黑色素瘤的免疫治疗效果，但由于证据不足，需要更多的数据来证明这一点。而对于胃癌，其影响仍存在争议。应注意系统性相关癌症中涉及的感染调节作用和代谢。在进行免疫治疗时是否应该消除感染可能是某些肿瘤的一个关键考虑因素。
