Department of Internal Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Graduate School of Heilongjiang University of Chinese Medicine, Harbin, China.
Front Cell Infect Microbiol. 2023 Apr 14;13:1062803. doi: 10.3389/fcimb.2023.1062803. eCollection 2023.
Gastric cancer (GC), a common and high-mortality disease, still occupies an important position in current cancer research, and () infection as its important risk factor has been a hot and challenging research area. Among the numerous pathogenic factors of , the virulence protein CagA has been widely studied as the only bacterial-derived oncoprotein. It was found that CagA entering into gastric epithelial cells (GECs) can induce the dysregulation of multiple cellular pathways such as MAPK signaling pathway, PI3K/Akt signaling pathway, NF-κB signaling pathway, Wnt/β-catenin signaling pathway, JAK-STAT signaling pathway, Hippo signaling pathway through phosphorylation and non-phosphorylation. These disordered pathways cause pathological changes in morphology, adhesion, polarity, proliferation, movement, and other processes of GECs, which eventually promotes the occurrence of GC. With the deepening of -related research, the research on CagA-induced abnormal signaling pathway has been updated and deepened to some extent, so the key signaling pathways activated by CagA are used as the main stem to sort out the pathogenesis of CagA in this paper, aiming to provide new strategies for the infection and treatment of GC in the future.
胃癌（GC）是一种常见且死亡率较高的疾病，在当前癌症研究中仍占有重要地位，而（）感染作为其重要的危险因素一直是一个热门且具有挑战性的研究领域。在众多致病因素中，毒力蛋白 CagA 作为唯一的细菌源性癌蛋白已被广泛研究。研究发现，进入胃上皮细胞（GECs）的 CagA 可通过磷酸化和非磷酸化诱导 MAPK 信号通路、PI3K/Akt 信号通路、NF-κB 信号通路、Wnt/β-catenin 信号通路、JAK-STAT 信号通路、Hippo 信号通路等多个细胞通路失调。这些紊乱的通路导致 GECs 在形态、黏附、极性、增殖、运动等过程中的病理性变化，最终促进 GC 的发生。随着对 - 相关研究的深入，CagA 诱导的异常信号通路的研究在一定程度上得到了更新和深化，因此本文以 CagA 激活的关键信号通路为主要线索，梳理 CagA 在其中的发病机制，以期为未来 - 感染和 GC 的治疗提供新策略。
