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孕期及幼年时期接触花粉与儿童哮喘发病率有关。

Pollen exposures in pregnancy and early life are associated with childhood asthma incidence.

作者信息

Melaram Rajesh, Adefisoye James, Warden Donald E, Potter Stephen, Arshad Hasan, Zhang Hongmei

机构信息

College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, TX, USA.

Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.

出版信息

World Allergy Organ J. 2024 Oct 5;17(10):100976. doi: 10.1016/j.waojou.2024.100976. eCollection 2024 Oct.

DOI:10.1016/j.waojou.2024.100976
PMID:39435152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11491945/
Abstract

BACKGROUND

Pollen exposure is an environmental risk factor for asthma symptoms and allergic reactions in children. The extent to which pollen exposure in pregnancy and the first year of life influences the development of childhood asthma and rhinitis is not fully understood.

OBJECTIVE

We aimed to investigate early life exposures to pollen with childhood asthma and rhinitis at age 6 in a longitudinal birth cohort of the United Kingdom.

METHODS

In this retrospective cohort study, via logistic regressions, we analyzed the associations between pollen exposures in pregnancy and the first year of life with childhood asthma and rhinitis.

RESULTS

Higher pollen exposure accumulated during pregnancy and during the first year of life both associated with an increased odds of asthma at age 6 (OR = 1.14, 95% CI 1.03-1.26, p = 0.01; OR = 1.15, 95% CI 1.03-1.29, p = 0.02, respectively). We did not observe statistically significant associations between early life pollen exposures and the odds of rhinitis at the same age.

CONCLUSION

High pollen exposure during early life (prenatal and postnatal) associated with an increased risk of asthma incidence at age 6. Further studies are desired to validate these findings and to elucidate the mechanisms of early life exposures to pollen on asthma etiology.

摘要

背景

花粉暴露是儿童哮喘症状和过敏反应的一个环境风险因素。孕期和出生后第一年的花粉暴露对儿童哮喘和鼻炎发展的影响程度尚未完全明确。

目的

我们旨在对英国一个纵向出生队列中6岁儿童的早期花粉暴露与哮喘和鼻炎情况进行调查。

方法

在这项回顾性队列研究中，我们通过逻辑回归分析了孕期和出生后第一年的花粉暴露与儿童哮喘和鼻炎之间的关联。

结果

孕期和出生后第一年累积的较高花粉暴露均与6岁时哮喘几率增加相关（比值比分别为1.14，95%置信区间1.03 - 1.26，p = 0.01；1.15，95%置信区间1.03 - 1.29，p = 0.02）。我们未观察到早期花粉暴露与同年龄鼻炎几率之间存在统计学显著关联。

结论

生命早期（产前和产后）的高花粉暴露与6岁时哮喘发病风险增加相关。需要进一步研究来验证这些发现，并阐明生命早期花粉暴露对哮喘病因的作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1665/11491945/91ce34f950d8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1665/11491945/91ce34f950d8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1665/11491945/91ce34f950d8/gr1.jpg

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