Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan ; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Department of Pharmacy, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan ; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
PLoS One. 2013 Nov 20;8(11):e80285. doi: 10.1371/journal.pone.0080285. eCollection 2013.
Bronchial asthma (BA), atopic dermatitis (AD), and allergic rhinitis (AR) are common allergic diseases. Environmental factors were indicated to influence the development of allergic diseases.
To evaluate the correlation between the month of birth and the prevalence of allergic diseases in Taiwan.
Data from 104,455 children were collected from the National Insurance Research Database of Taiwan. Subjects were identified by at least two service claims for ambulatory care or one claim for inpatient care. All of the enrolled patients were aged 7∼15 years in 2010. In a bio-clinical data analysis, total immunoglobulin E (IgE) and ImmunoCAP™ allergen data (CAP) from mothers and infants were collected in a medical center in Taiwan. Correlations between children's allergic factors and the season of birth were assessed.
A significant difference in the prevalence of BA according to the month of birth (Χ(2) = 18.2, p<0.001) was found in the Taiwanese population. The fewest schoolchildren with were born in May (7.21%), and the most were born in October (10.59%). However, no tendency for the prevalence of AD (Χ(2) = 4.6, P = 0.204) or AR (Χ(2) = 4.3 P = 0.229) was found. In addition, we found that children born in autumn (August to October) had a higher prevalence of BA compared to those born in spring (February to April) (odds ratio: 1.13; 95% confidence interval: 1.05∼1.21). In a bio-clinical data study, markers of maternal and childhood allergies including IgE and CAP were detected in a risk analysis section. Children who were born in autumn had higher levels of CAP and total IgE.
The findings of this study showed that the month of birth was closely correlated with the prevalence of BA and higher levels of CAP and IgE.
支气管哮喘（BA）、特应性皮炎（AD）和过敏性鼻炎（AR）是常见的过敏性疾病。环境因素被认为会影响过敏性疾病的发展。
评估台湾地区出生月份与过敏性疾病患病率之间的相关性。
从台湾全民健康保险研究数据库中收集了 104455 名儿童的数据。通过至少两次门诊护理服务索赔或一次住院护理索赔来确定研究对象。所有入组患者在 2010 年均为 7∼15 岁。在一项生物临床数据分析中，从台湾一家医疗中心收集了母亲和婴儿的总免疫球蛋白 E（IgE）和 ImmunoCAP™过敏原数据（CAP）。评估了儿童过敏因素与出生季节之间的相关性。
在台湾人群中，根据出生月份，BA 的患病率存在显著差异（Χ(2) = 18.2，p<0.001）。五月份出生的学童最少（7.21%），十月份出生的最多（10.59%）。然而，AD（Χ(2) = 4.6，P = 0.204）或 AR（Χ(2) = 4.3，P = 0.229）的患病率没有趋势。此外，我们发现秋季（8 月至 10 月）出生的儿童患 BA 的比例高于春季（2 月至 4 月）（优势比：1.13；95%置信区间：1.05∼1.21）。在一项生物临床数据分析中，在风险分析部分检测了包括 IgE 和 CAP 在内的母婴过敏标志物。秋季出生的儿童 CAP 和总 IgE 水平较高。
本研究结果表明，出生月份与 BA 患病率以及 CAP 和 IgE 水平密切相关。
