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喉切除术后吻合器辅助咽闭合术结局的配对分析。

A matched pair analysis of outcomes after stapler-assisted pharyngeal closure following laryngectomy.

作者信息

Paulose Antony Abraham, Michael Rajiv Charles, Ramalingam Natarajan, Riju Jeyashanth, Gowri S Mahasampath, Abraham Lisa, Johns L Jino, Mathew Manu, Thomas Meera, Irodi Aparna

机构信息

Department of Head and Neck Surgery, Christian Medical College, Vellore, India.

Department of Biostatistics, Christian Medical College, Vellore, India.

出版信息

J Laryngol Otol. 2025 Jan;139(1):78-84. doi: 10.1017/S0022215124001269. Epub 2024 Oct 22.

Abstract

OBJECTIVE

To compare perioperative and oncological outcomes between stapler and manual closure in patients undergoing total laryngectomy for advanced endolaryngeal squamous cell carcinoma.

METHODS

Patients with advanced endolaryngeal tumours operated between July 2017 and July 2023 were retrospectively dichotomised into stapler closure and manual closure cohorts and compared.

RESULTS

Seventy-one patients with a median age of 57 years were included in our study. The median surgical duration was 270 minutes for the manual closure cohort and 245 minutes for the stapler closure cohort. The pharyngo-cutaneous salivary fistula rate was 6 per cent less in the stapler closure cohort. The estimated mean survival was not significantly different 54.5 months (95 per cent, confidence interval 46.3-62.71) in the manual closure cohort versus 28.12 months (95 per cent, confidence interval 23.6-32.63) in the stapler closure cohort ( = 0.79).

CONCLUSION

Stapler closure can be used in endolaryngeal tumours, and it reduces operating time, thus facilitating efficient utilisation of operation time with non-inferior oncological outcomes as compared to traditional manual closure.

摘要

目的

比较晚期喉内鳞状细胞癌患者行全喉切除术时吻合器闭合与手工闭合的围手术期及肿瘤学结局。

方法

回顾性分析2017年7月至2023年7月间接受手术治疗的晚期喉内肿瘤患者,将其分为吻合器闭合组和手工闭合组并进行比较。

结果

本研究纳入71例患者,中位年龄57岁。手工闭合组的中位手术时间为270分钟,吻合器闭合组为245分钟。吻合器闭合组咽皮肤唾液瘘发生率低6%。手工闭合组的估计平均生存期为54.5个月(95%置信区间46.3 - 62.71),与吻合器闭合组的28.12个月(95%置信区间23.6 - 32.63)相比,差异无统计学意义(P = 0.79)。

结论

吻合器闭合可用于喉内肿瘤,它能缩短手术时间,因此与传统手工闭合相比,在肿瘤学结局不劣的情况下,有利于高效利用手术时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef7/12303712/45b280705161/S0022215124001269_fig1.jpg

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