脑室注射血清后大鼠中枢神经系统的髓鞘变化

Myelin changes in the rats CNS following intraventricular injection of serum.

作者信息

Konat G, Diemer N H, Offner H

出版信息

Experientia. 1986 Jan 15;42(1):37-9. doi: 10.1007/BF01975883.

DOI:10.1007/BF01975883

Abstract

Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.

摘要

通过脑室内注射给予正常人类或大鼠血清，可诱导大鼠中枢神经系统髓鞘发生明显变化，这从组织匀浆中解离髓鞘（DM）（即与髓鞘相关的低密度膜碎片）回收率增加可以看出。DM的产量在注射后第3天达到最大值，并在第5天恢复到对照水平。尽管DM的回收率增加，但未检测到髓鞘分离物的物理化学改变，也未检测到组织中的组织学异常。DM的产生似乎是血清诱导髓鞘鞘膜改变的敏感指标。