The effect of serum from multiple sclerosis patients in remission on the incubated rat brain slices.
作者信息
Konat G, Offner H, Zeeberg I
出版信息
J Neurol Sci. 1983 Aug-Sep;60(3):363-6. doi: 10.1016/0022-510x(83)90146-6.
PMID:6631442
Abstract
Addition of human serum to incubated rat cerebral slices induced increased generation of myelin-related, membranous fragments floating on 0.32 M sucrose. Sera from 20 healthy subjects and 19 patients with various neurological disorders were equally active in this respect. On the other hand, the myelin-degrading activity of sera from 20 multiple sclerosis patients in remission was found to be significantly elevated by about 50%. The present findings support the contention that the serum of multiple sclerosis patients possesses increased potency to induce myelin sheath alterations.
摘要
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