Bunting L A, Neilson J B, Bulmer G S
Sabouraudia. 1979 Sep;17(3):225-32. doi: 10.1080/00362177985380341.
During 7 days of incubation in vitro the trophozoite stage of the free-living soil amoeba, Acanthamoeba polyphaga, phagocytized and killed 78-97% of the cells of three strains of Cryptococcus neoformans. With one strain, incubation time was increased to nine days and 99% of the yeast cells were killed. It was calculated that during 4-9 days of incubation a single trophozoite phagocytized and killed a daily average of 84 yeast cells. The lethal effect of A. polyphaga on C. neoformans may represent a biological control mechanism in nature. Some of the surviving cells of C. neoformans developed into colonies containing pseudohyphae; these pseudolhyphal forms may be a biological 'escape hatch'.
在体外培养7天期间，自由生活的土壤变形虫多噬棘阿米巴的滋养体阶段吞噬并杀死了三株新型隐球菌78% - 97%的细胞。对于其中一株，培养时间延长至9天，99%的酵母细胞被杀死。据计算，在培养4 - 9天期间，单个滋养体每天平均吞噬并杀死84个酵母细胞。多噬棘阿米巴对新型隐球菌的致死作用可能代表了自然界中的一种生物控制机制。一些存活的新型隐球菌细胞发育成含有假菌丝的菌落；这些假菌丝形式可能是一种生物“逃生舱口”。
