正常巨噬细胞和巯基乙酸盐激活的巨噬细胞对新型隐球菌的吞噬作用。
Phagocytosis of Cryptococcus neoformans by normal and thioglycolate-activated macrophages.
作者信息
Swenson F J, Kozel T R
出版信息
Infect Immun. 1978 Sep;21(3):714-20. doi: 10.1128/iai.21.3.714-720.1978.
Abstract
Phagocytosis of Cryptococcus neoformans by normal and thioglycolate-activated mouse peritoneal macrophages was studied. Thioglycolate-activated macrophages exhibited a lower percent phagocytosis than did normal macrophages. Differences in phagocytosis could not be attributed to differences in macrophage viability, minor variations in the concentration of adherent macrophages, or a general depression in activated macrophage phagocytosis. Thioglycolate-activated macrophages required heat-labile opsonins for optimal phagocytosis of non-encapsulated cryptococci, whereas nonactivated macrophages did not require heat-labile opsonins for phagocytosis of the yeast. Both types of macrophages exhibited similar sensitivity to the phagocytosis-inhibiting properties of cryptococcal polysaccharide. The results show that depletion of heat-labile opsonins from serum or inactivation of yeast-bound, heat-labile opsonins by polysaccharide cannot account for the phagocytosis-inhibiting properties of cryptococcal polysaccharide.
摘要
研究了正常和巯基乙酸盐激活的小鼠腹腔巨噬细胞对新型隐球菌的吞噬作用。巯基乙酸盐激活的巨噬细胞的吞噬百分比低于正常巨噬细胞。吞噬作用的差异不能归因于巨噬细胞活力的差异、贴壁巨噬细胞浓度的微小变化或激活的巨噬细胞吞噬作用的普遍抑制。巯基乙酸盐激活的巨噬细胞吞噬非荚膜隐球菌需要热不稳定调理素，而未激活的巨噬细胞吞噬酵母不需要热不稳定调理素。两种类型的巨噬细胞对隐球菌多糖的吞噬抑制特性表现出相似的敏感性。结果表明，血清中热不稳定调理素的消耗或多糖对酵母结合的热不稳定调理素的失活不能解释隐球菌多糖的吞噬抑制特性。
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