Zhao Jianyou, Deng Chengling, Zhang Lanlan, Zhang Jiatai, Rong Quanjin, Wang Fan, Liu Zhong-Quan
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
J Org Chem. 2024 Nov 1;89(21):15864-15876. doi: 10.1021/acs.joc.4c02007. Epub 2024 Oct 22.
A practical and recyclable electro-oxidation of alcohols to aldehydes and ketones by using -hydroxyphthalimide (NHPI) as the catalyst is presented. Through an undivided pool, under constant current conditions, various alcohols can be oxidized to the corresponding aldehydes or ketones in a high yield. Compared with previous methods, this system has the following characteristics: (1) the catalyst, electrode, electrolyte, and solvent (mainly water) are recyclable; (2) it has many advantages such as mild reaction conditions, easy operation, and good tolerance of functional groups; and (3) it can be smoothly scaled up to kilogram-scale production.
介绍了一种以N-羟基邻苯二甲酰亚胺（NHPI）为催化剂，将醇类实用且可循环的电氧化为醛和酮的方法。通过一个无隔膜电解池，在恒流条件下，各种醇类可以高产率地氧化为相应的醛或酮。与以前的方法相比，该体系具有以下特点：（1）催化剂、电极、电解质和溶剂（主要是水）可循环使用；（2）具有反应条件温和、操作简便、对官能团耐受性好等诸多优点；（3）可以顺利放大到千克级生产。
