Mater Amber, Boelen Anita, Heijboer Annemieke C, Hillebrand Jacquelien J
J Endocrinol. 2024 Dec 20;264(1). doi: 10.1530/JOE-24-0156. Print 2025 Jan 1.
Thyroid cancer is the most prevalent endocrine cancer, and the prognosis depends on the type and stage of cancer at the time of discovery. The treatment involves (hemi-)thyroidectomy, possibly followed by additional therapeutic options. After treatment, patients are monitored using serum concentrations of endocrine tumour markers: thyroglobulin (Tg) in case of differentiated cancer and calcitonin in case of medullary thyroid cancer. Measuring Tg and calcitonin concentrations in serum may be challenging. In this review, we provide a complete overview of the evolution in laboratory measurements of Tg and calcitonin, with an emphasis on (pre-)analytical challenges and potential approaches to overcome current pitfalls.
甲状腺癌是最常见的内分泌癌，其预后取决于发现时癌症的类型和阶段。治疗方法包括（半）甲状腺切除术，之后可能还会有其他治疗选择。治疗后，通过检测血清中内分泌肿瘤标志物的浓度对患者进行监测：分化型癌检测甲状腺球蛋白（Tg），髓样甲状腺癌检测降钙素。检测血清中Tg和降钙素的浓度可能具有挑战性。在本综述中，我们全面概述了Tg和降钙素实验室检测方法的发展，重点关注（分析前）挑战以及克服当前缺陷的潜在方法。
