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血浆 SQSTM1/p62 可作为激素诱导性股骨头坏死的生物标志物。

Plasma SQSTM1/p62 act as a biomarker for steroid-induced osteonecrosis of the femoral head.

机构信息

Guangzhou University of Chinese Medicine, Guangzhou, China.

Department of Orthopedics, Bijie Traditional Chinese Medicine Hospital, Bijie, China.

出版信息

Sci Rep. 2024 Oct 22;14(1):24932. doi: 10.1038/s41598-024-71743-2.

DOI:10.1038/s41598-024-71743-2
PMID:39438530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11496759/
Abstract

Autophagy is closely associated with the onset and progression of steroid-induced osteonecrosis of the femoral head (SIONFH). SQSTM1/p62 is an important indicator of autophagic activity. The aim of this study was to investigate the role of SQSTM1/p62 in the development of SIONFH. From May 2021 through November 2021, 36 patients diagnosed with SIONFH and 36 healthy controls were recruited for this study. Evaluations included imaging and pathologic assessment of clinical bone tissue, location and level of SQSTM1/p62 expression, plasma SQSTM1/p62 levels, and receiver operating characteristic (ROC) curves. We observed that the expression level of SQSTM1/p62 in bone samples decreased with the Association Research Circulation Osseous (ARCO) phase. Plasma SQSTM1/p62 levels were significantly higher in the SIONFH group compared to healthy controls. Plasma SQSTM1/p62 levels were higher in pre-crash patients than in post-crash patients, and lower plasma SQSTM1/p62 levels were associated with elevated ARCO stage. Plasma SQSTM1/p62 may represent a potential biomarker for different stages during SIONFH. Lower plasma SQSTM1/p62 levels indicate an advanced stage of SIONFH. This study provides new clues for early diagnosis of SIONFH.

摘要

自噬与激素诱导性股骨头坏死（SIONFH）的发生和进展密切相关。SQSTM1/p62 是自噬活性的重要指标。本研究旨在探讨 SQSTM1/p62 在 SIONFH 发展中的作用。本研究纳入了 2021 年 5 月至 2021 年 11 月的 36 例 SIONFH 患者和 36 例健康对照者。评估内容包括临床骨组织的影像学和病理学评估、SQSTM1/p62 表达的位置和水平、血浆 SQSTM1/p62 水平以及受试者工作特征（ROC）曲线。我们观察到，骨样本中 SQSTM1/p62 的表达水平随 Association Research Circulation Osseous（ARCO）分期降低。SIONFH 组患者的血浆 SQSTM1/p62 水平明显高于健康对照组。在未塌陷患者中，血浆 SQSTM1/p62 水平高于塌陷后患者，较低的血浆 SQSTM1/p62 水平与 ARCO 分期升高相关。血浆 SQSTM1/p62 可能是 SIONFH 不同阶段的潜在生物标志物。较低的血浆 SQSTM1/p62 水平表明 SIONFH 处于晚期阶段。本研究为 SIONFH 的早期诊断提供了新的线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/95a11332dda5/41598_2024_71743_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/61ba24e046ea/41598_2024_71743_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/4cbbfeb0e19e/41598_2024_71743_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/570db2636b75/41598_2024_71743_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/d41c1cb4ecc7/41598_2024_71743_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/95a11332dda5/41598_2024_71743_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/61ba24e046ea/41598_2024_71743_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/4cbbfeb0e19e/41598_2024_71743_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/570db2636b75/41598_2024_71743_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/d41c1cb4ecc7/41598_2024_71743_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1027/11496759/95a11332dda5/41598_2024_71743_Fig5_HTML.jpg

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Autophagy: Regulator of cell death.
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