Leffler C W, Hessler J R, Green R S, Fletcher A M
Hypertension. 1986 Jan;8(1):62-5. doi: 10.1161/01.hyp.8.1.62.
This study investigated the effects of NaCl supplementation (5 mEq/kg/day) on the arterial pressure of pregnant and nonpregnant sheep with and without reduction of uteroplacental perfusion pressure. In pregnant sheep receiving NaCl supplementation during the third trimester, reduction of aortic pressure caudal to the kidneys to 65% of the upstream pressure (occlusion) caused a progressive increase in mean arterial pressure from 89 +/- 3 to 110 +/- 3 mm Hg over 2 weeks. Occlusion was accompanied by a decrease in urine flow. Six of seven sheep died or were killed because of severe respiratory distress. No abnormalities were detected in nonpregnant sheep or pregnant sheep receiving NaCl supplementation only. Pregnant sheep that were occluded but received no supplementary NaCl did not become hypertensive but aborted about 2 weeks after occlusion. These results indicate that reduction of uteroplacental perfusion pressure causes hypertension in NaCl-supplemented pregnant sheep but not in sheep receiving a normal, low sodium diet.
本研究调查了补充氯化钠（5 毫当量/千克/天）对有或无子宫胎盘灌注压降低的妊娠和非妊娠绵羊动脉血压的影响。在妊娠晚期接受氯化钠补充的妊娠绵羊中，将肾尾端主动脉压降至上游压力的65%（闭塞），导致平均动脉压在2周内从89±3毫米汞柱逐渐升高至110±3毫米汞柱。闭塞伴随着尿流量减少。7只绵羊中有6只因严重呼吸窘迫死亡或被处死。在非妊娠绵羊或仅接受氯化钠补充的妊娠绵羊中未检测到异常。被闭塞但未补充氯化钠的妊娠绵羊未出现高血压，但在闭塞后约2周流产。这些结果表明，子宫胎盘灌注压降低会导致补充氯化钠的妊娠绵羊高血压，但不会导致接受正常低钠饮食的绵羊高血压。
