Tawara A
Invest Ophthalmol Vis Sci. 1986 Feb;27(2):226-36.
Ocular tissues from two enucleated and one trabeculectomized human eyes with siderosis bulbi were studied by electron microscopy. Ferritin particles were demonstrated in various cell types of the three eyes. Other types of iron were not identifiable. The ferritin particles were scattered throughout the cytoplasm, with a few particles in the nucleus and extracellular space. More ferritin particles were seen in tissues near the iron foreign body. The cells which contained numerous ferritin particles also had siderosomes, most of which were thought to be conglomerates of the ferritin particles in the secondary lysosomes. Cells with numerous ferritin particles, particularly in the siderosomes, showed vacuolar degeneration. The present study indicated that in siderosis bulbi, iron released from the iron foreign body is deposited as ferritin scattered throughout the cytoplasm and is sometimes accumulated as siderosomes, in the affinitive cells. In siderosis bulbi, the cells become damaged by the deposition of ferritin in the cytoplasm, especially in the form of siderosomes.
对两只摘除眼球和一只患有眼球铁锈症并接受小梁切除术的人眼的眼组织进行了电子显微镜研究。在三只眼睛的各种细胞类型中均发现了铁蛋白颗粒。未发现其他类型的铁。铁蛋白颗粒散布于整个细胞质中，细胞核和细胞外空间中也有少量颗粒。在靠近铁异物的组织中可见到更多的铁蛋白颗粒。含有大量铁蛋白颗粒的细胞也有含铁小体，其中大多数被认为是次级溶酶体中铁蛋白颗粒的聚集体。含有大量铁蛋白颗粒的细胞，尤其是含铁小体中的细胞，表现出空泡变性。本研究表明，在眼球铁锈症中，从铁异物释放的铁以铁蛋白的形式沉积在整个细胞质中，有时以含铁小体的形式积聚在亲和细胞中。在眼球铁锈症中，细胞因铁蛋白在细胞质中的沉积而受损，尤其是以含铁小体的形式。
