Hazarika Disha, Sarma Sumit, Shankarishan Priyanka
University of Science and Technology Meghalaya (USTM), Meghalaya, India.
BioTechnologia (Pozn). 2024 Sep 30;105(3):287-303. doi: 10.5114/bta.2024.141807. eCollection 2024.
Nanotechnology presents an exciting opportunity in cancer research by offering significant advancements in therapies, diagnosis, and management. It possesses unparalleled potential to enhance the accuracy and effectiveness of cancer therapy while simultaneously reducing adverse effects, owing to its distinctive capability to manipulate matter at a molecular level. Using nanoparticle carriers has facilitated the precise administration of therapeutic agents to afflicted areas within the human body through customized drug delivery systems, resulting in improved treatment accuracy and efficacy while reducing adverse effects. These techniques improve drug solubility and stability, leading to elevated levels of biochemical availability and improved efficacy outcomes for patients with minimal negative effects during treatment cycles. Another use case for nanoparticles includes tumor imaging; functionalized with targeting ligands containing diagnostic agents, they foster early detection, making quicker remedial action plans possible. Overall, the incorporation of nanotechnology ensures a promising future, although it stresses the need to address regulatory hurdles and safety concerns before widespread clinical implementation. Despite the complexity of cancer research and patient care, nanotechnology shows promise in transforming both fields.
纳米技术在癌症研究中提供了一个令人兴奋的机会，在治疗、诊断和管理方面取得了重大进展。由于其在分子水平上操纵物质的独特能力，它具有无与伦比的潜力来提高癌症治疗的准确性和有效性，同时减少不良反应。使用纳米颗粒载体通过定制的药物递送系统促进了治疗剂在人体内患病区域的精确给药，从而提高了治疗的准确性和疗效，同时减少了不良反应。这些技术提高了药物的溶解度和稳定性，从而提高了生化利用度，改善了治疗效果，且在治疗周期中对患者的负面影响最小。纳米颗粒的另一个应用案例是肿瘤成像；用含有诊断剂的靶向配体进行功能化后，它们有助于早期检测，从而制定更快的补救行动计划。总体而言，尽管纳米技术强调在广泛临床应用之前需要解决监管障碍和安全问题，但它的应用确保了一个充满希望的未来。尽管癌症研究和患者护理很复杂，但纳米技术在改变这两个领域方面显示出了前景。
