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推进纳米技术以改善癌症靶向治疗:克服其临床实施中的障碍。

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation.

机构信息

Novin Genome (NG) Institute, Research and Development Center for Biotechnology, Shahrekord, Chaharmahal and Bakhtiari, Iran.

Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Chaharmahal and Bakhtiari, Iran.

出版信息

Mol Cancer. 2023 Oct 9;22(1):169. doi: 10.1186/s12943-023-01865-0.

Abstract

The use of nanotechnology has the potential to revolutionize the detection and treatment of cancer. Developments in protein engineering and materials science have led to the emergence of new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers for medicinal purposes have been approved for human trials, only a few have been authorized for clinical use in targeting cancer cells. In this review, we analyze some of the authorized formulations and discuss the challenges of translating findings from the lab to the clinic. This study highlights the various nanocarriers and compounds that can be used for selective tumor targeting and the inherent difficulties in cancer therapy. Nanotechnology provides a promising platform for improving cancer detection and treatment in the future, but further research is needed to overcome the current limitations in clinical translation.

摘要

纳米技术的应用有潜力彻底改变癌症的检测和治疗方式。蛋白质工程和材料科学的发展催生了新的纳米级靶向技术,为癌症患者带来了新的希望。虽然已经有几种用于医疗目的的纳米载体获得了人体试验的批准,但只有少数几种被授权用于靶向癌细胞的临床应用。在这篇综述中,我们分析了一些已授权的制剂,并讨论了将实验室研究成果转化为临床应用的挑战。本研究强调了可用于选择性肿瘤靶向的各种纳米载体和化合物,以及癌症治疗中固有的困难。纳米技术为未来改善癌症的检测和治疗提供了一个有前途的平台,但需要进一步的研究来克服目前临床转化中的限制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/387d/10561438/fda6c6bee119/12943_2023_1865_Fig1_HTML.jpg

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