免疫细胞动力学及其对肝癌患者经血管抗肿瘤介入治疗效果的影响。
Immune cell dynamics and the impact on the efficiency of transvascular antitumor interventional therapies in hepatocellular carcinoma patients.
机构信息
Department of Interventional Radiology, Shandong Cancer Hospital and Institute Affiliated Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China.
Key Laboratory of Transplant Engineering and Immunology, National Health Commission (NHC), Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
出版信息
Front Immunol. 2024 Oct 8;15:1450525. doi: 10.3389/fimmu.2024.1450525. eCollection 2024.
OBJECTIVE
This study investigates the impact of transvascular antitumor interventional therapies on immune cell dynamics and its correlation with disease control and progression-free survival (PFS) in hepatocellular carcinoma (HCC) patients.
METHODS
A single-center observational case-control study was conducted with 119 HCC patients. Transvascular antitumor interventional therapy were administered based on patient-specific evaluations. Peripheral blood samples were collected before and within 28 days after the first treatment to analyze lymphocyte subsets and other immune cells.
RESULTS
Higher counts of total white blood cells (WBCs), lymphocytes, monocytes, and basophils were significantly associated with disease control rate. Subgroup analysis revealed that abnormal BMI, diabetes, infection, and multiple lesions were significantly associated with T cell abnormalities. Age, abnormal BMI, hypertension, and abnormal AFP were linked to total T cell abnormalities. NK cells, B cells, Th cells, Tc/Ts cells, and CD4/CD8 ratios did not show significant differences in PFS probabilities.
CONCLUSION
Higher counts of WBCs, lymphocytes, monocytes, and basophils, play a crucial role in the effectiveness of HCC interventional therapy.
目的
本研究旨在探讨经血管抗肿瘤介入治疗对肝癌（HCC）患者免疫细胞动力学的影响及其与疾病控制和无进展生存期（PFS）的相关性。
方法
采用单中心观察性病例对照研究，纳入 119 例 HCC 患者。根据患者的具体情况进行经血管抗肿瘤介入治疗。在首次治疗前和治疗后 28 天内采集外周血样本，分析淋巴细胞亚群和其他免疫细胞。
结果
总白细胞（WBC）、淋巴细胞、单核细胞和嗜碱性粒细胞计数较高与疾病控制率显著相关。亚组分析显示，异常 BMI、糖尿病、感染和多发病变与 T 细胞异常显著相关。年龄、异常 BMI、高血压和异常 AFP 与总 T 细胞异常相关。NK 细胞、B 细胞、Th 细胞、Tc/Ts 细胞和 CD4/CD8 比值与 PFS 概率无显著差异。
结论
较高的 WBC、淋巴细胞、单核细胞和嗜碱性粒细胞计数在 HCC 介入治疗的疗效中起着关键作用。
Zotero 插件