Wang Shifu, Yang Shangmin, Ma Jing, Zhang Chunyan, Li Zheng, Wang Mengyuan, Yu Wenwen, Liu Guohua
Department of Microbiology Laboratory, Children's Hospital Affiliated to Shandong University, Jinan, China.
Shandong Provincial Clinical Research Center for Children's Health and Disease, Jinan, China.
Front Med (Lausanne). 2024 Oct 8;11:1387278. doi: 10.3389/fmed.2024.1387278. eCollection 2024.
Coinfections or consecutive infections of and are exceedingly uncommon in children, we report the case to offer the valuable experience for colleagues facing similar situations.
This report documents the first recorded case of successful treatment for pulmonary mixed infection in a diabetic girl. Initially, the patient underwent treatment based on voriconazole, but the infection continued to deteriorate. Subsequently, bronchoalveolar lavage fluid culture and metagenomic next-generation sequencing (mNGS) were conducted, leading to a clear diagnosis of simultaneous infection by and . Susceptibility testing revealed fungal resistance to voriconazole. Therefore, a combined treatment regimen of AmB liposomes and isavuconazole effectively eradicated the fungal infection.
This case underscores the importance of early and precise identification of fungal pathogens, determination of effective antifungal medications, and timely implementation of well-planned therapeutic strategies. Furthermore, we comprehensively reviewed 10 cases of pulmonary mixed infections involving and , summarizing their characteristics and identifying commonalities.
儿童同时感染或相继感染[具体两种病原体未给出]极为罕见，我们报告此病例，为面临类似情况的同行提供宝贵经验。
本报告记录了首例成功治疗糖尿病女孩肺部混合感染的病例。最初，患者接受伏立康唑治疗，但感染持续恶化。随后进行了支气管肺泡灌洗 fluid 培养和宏基因组下一代测序（mNGS），明确诊断为同时感染[具体两种病原体未给出]。药敏试验显示真菌对伏立康唑耐药。因此，两性霉素 B 脂质体和艾沙康唑联合治疗方案有效根除了真菌感染。
本病例强调了早期准确鉴定真菌病原体、确定有效的抗真菌药物以及及时实施精心规划的治疗策略的重要性。此外，我们全面回顾了 10 例涉及[具体两种病原体未给出]的肺部混合感染病例，总结了它们的特征并找出了共性。
