Ribatti Domenico
Department of Translational Biomedicine and Neuroscience, University of Bari Medical School, Bari, Italy.
Front Med (Lausanne). 2024 Oct 8;11:1481609. doi: 10.3389/fmed.2024.1481609. eCollection 2024.
The tumor microenvironment comprises diverse cell types, including T and B lymphocytes, macrophages, dendritic cells, natural killer cells, myeloid-derived suppressor cells, neutrophils, eosinophils, mast cells, and fibroblasts. Cells in the tumor microenvironment can be either tumor-suppressive or tumor-supporting cells. In this review article, we analyze the double role played by tumor macrophages, tumor neutrophils, tumor mast cells, and tumor fibroblasts, in promoting angiogenesis during tumor progression. Different strategies to target the tumor microenvironment have been developed in this context, including the depletion of tumor-supporting cells, or their "re-education" as tumor-suppressor cells.
肿瘤微环境由多种细胞类型组成，包括T淋巴细胞、B淋巴细胞、巨噬细胞、树突状细胞、自然杀伤细胞、髓源性抑制细胞、中性粒细胞、嗜酸性粒细胞、肥大细胞和成纤维细胞。肿瘤微环境中的细胞可以是肿瘤抑制细胞或肿瘤支持细胞。在这篇综述文章中，我们分析了肿瘤巨噬细胞、肿瘤中性粒细胞、肿瘤肥大细胞和肿瘤成纤维细胞在肿瘤进展过程中促进血管生成方面所起的双重作用。在此背景下，已经开发出了针对肿瘤微环境的不同策略，包括清除肿瘤支持细胞，或将它们“重新教育”为肿瘤抑制细胞。
