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本文引用的文献

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Molecular characterization of SARS-CoV-2 Omicron clade and clinical presentation in children.奥密克戎变异株的分子特征及儿童临床表现。
Sci Rep. 2024 Mar 4;14(1):5325. doi: 10.1038/s41598-024-55599-0.
2
Genomic Epidemiology and Lineage Dynamics of SARS-CoV-2 in Bulgaria: Insights from a Three-Year Pandemic Analysis.保加利亚的 SARS-CoV-2 基因组流行病学和谱系动态:三年大流行分析的见解。
Viruses. 2023 Sep 15;15(9):1924. doi: 10.3390/v15091924.
3
Ancestral Origin and Dissemination Dynamics of Reemerging Toxigenic Vibrio cholerae, Haiti.海地重现产毒霍乱弧菌的祖先起源和传播动态。
Emerg Infect Dis. 2023 Oct;29(10):2072-2082. doi: 10.3201/eid2910.230554.
4
Viral load dynamics of SARS-CoV-2 Delta and Omicron variants following multiple vaccine doses and previous infection.接种多剂疫苗和既往感染后 SARS-CoV-2 德尔塔和奥密克戎变异株的病毒载量动态。
Nat Commun. 2022 Nov 7;13(1):6706. doi: 10.1038/s41467-022-33096-0.
5
SARS-CoV-2 infections in infants in Haiti 2020-2021; evidence from a seroepidemiological cohort.2020-2021 年海地婴儿中严重急性呼吸综合征冠状病毒 2 型感染;来自血清流行病学队列的证据。
PLoS One. 2022 Aug 25;17(8):e0273482. doi: 10.1371/journal.pone.0273482. eCollection 2022.
6
The displacement of the SARS-CoV-2 variant Delta with Omicron: An investigation of hospital admissions and upper respiratory viral loads.德尔塔变异株被奥密克戎取代:对住院和上呼吸道病毒载量的调查。
EBioMedicine. 2022 May;79:104008. doi: 10.1016/j.ebiom.2022.104008. Epub 2022 Apr 20.
7
Severe Acute Respiratory Syndrome Coronavirus 2 Delta Vaccine Breakthrough Transmissibility in Alachua County, Florida.佛罗里达州阿拉楚阿县严重急性呼吸综合征冠状病毒 2 型德尔塔疫苗突破性传播。
Clin Infect Dis. 2022 Oct 29;75(9):1618-1627. doi: 10.1093/cid/ciac197.
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How does Omicron spread so fast? A high viral load isn't the answer.奥密克戎为何传播如此之快?高病毒载量并非答案。
Nature. 2022 Jan 19. doi: 10.1038/d41586-022-00129-z.
9
Rapid Emergence and Spread of Severe Acute Respiratory Syndrome Coronavirus 2 Gamma (P.1) Variant in Haiti.海地严重急性呼吸系统综合征冠状病毒 2 伽马(P.1)变异株的快速出现和传播。
Clin Infect Dis. 2022 Jun 10;74(11):2057-2060. doi: 10.1093/cid/ciab736.
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Ultrafast Sample placement on Existing tRees (UShER) enables real-time phylogenetics for the SARS-CoV-2 pandemic.超快现有树木样本放置 (UShER) 可实现 SARS-CoV-2 大流行的实时系统发生学。
Nat Genet. 2021 Jun;53(6):809-816. doi: 10.1038/s41588-021-00862-7. Epub 2021 May 10.

疫苗接种率极低的岛屿人群中的2019冠状病毒病谱系:海地严重急性呼吸综合征冠状病毒2的基因组流行病学

Coronavirus Disease 2019 Lineages in a Minimally Vaccinated Island Population: Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in Haiti.

作者信息

Mavian Carla N, Tagliamonte Massimiliano S, Bassett Maclean, Alam Meer T, Cash Melanie N, Hitchings Matt, Louis Rigan, Riva Alberto, Zainabadi Kayvan, Deschamps Marie Marcelle, Liautaud Bernard, Rouzier Vanessa, Fitzgerald Daniel W, Pape Jean William, Morris J Glenn, Salemi Marco

机构信息

Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.

出版信息

J Infect Dis. 2025 Feb 20;231(2):386-391. doi: 10.1093/infdis/jiae520.

DOI:10.1093/infdis/jiae520
PMID:39440935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11841648/
Abstract

We monitored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in Haiti from 2020 to 2023. Despite Haitian coronavirus disease 2019 (COVID-19) travel restrictions and in the setting of a vaccination rate of 2.7%, the timing and lineage evolution of the Haiti epidemic mirrored what was occurring in the rest of the world. Sources for importation of lineages into Haiti were the United States, the Dominican Republic, Europe, and Brazil, with exportation of lineages to the United States, the Dominican Republic, Europe, and Asia. Viral loads in patients infected by the Delta and Omicron BA.1 variants were correlated along the phylogenies, suggesting that higher viral loads have facilitated strain transmission and evolution.

摘要

2020年至2023年期间,我们对海地的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)变体进行了监测。尽管海地实施了2019冠状病毒病(COVID-19)旅行限制,且疫苗接种率仅为2.7%,但海地疫情的时间和谱系演变与世界其他地区的情况相似。传入海地的谱系来源包括美国、多米尼加共和国、欧洲和巴西,传出的谱系则流向美国、多米尼加共和国、欧洲和亚洲。在系统发育树上,感染德尔塔和奥密克戎BA.1变体的患者的病毒载量具有相关性,这表明较高的病毒载量促进了毒株的传播和进化。