疫苗接种率极低的岛屿人群中的2019冠状病毒病谱系：海地严重急性呼吸综合征冠状病毒2的基因组流行病学
Coronavirus Disease 2019 Lineages in a Minimally Vaccinated Island Population: Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in Haiti.
作者信息
Mavian Carla N, Tagliamonte Massimiliano S, Bassett Maclean, Alam Meer T, Cash Melanie N, Hitchings Matt, Louis Rigan, Riva Alberto, Zainabadi Kayvan, Deschamps Marie Marcelle, Liautaud Bernard, Rouzier Vanessa, Fitzgerald Daniel W, Pape Jean William, Morris J Glenn, Salemi Marco
机构信息
Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.
出版信息
J Infect Dis. 2025 Feb 20;231(2):386-391. doi: 10.1093/infdis/jiae520.
We monitored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in Haiti from 2020 to 2023. Despite Haitian coronavirus disease 2019 (COVID-19) travel restrictions and in the setting of a vaccination rate of 2.7%, the timing and lineage evolution of the Haiti epidemic mirrored what was occurring in the rest of the world. Sources for importation of lineages into Haiti were the United States, the Dominican Republic, Europe, and Brazil, with exportation of lineages to the United States, the Dominican Republic, Europe, and Asia. Viral loads in patients infected by the Delta and Omicron BA.1 variants were correlated along the phylogenies, suggesting that higher viral loads have facilitated strain transmission and evolution.
2020年至2023年期间，我们对海地的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体进行了监测。尽管海地实施了2019冠状病毒病（COVID-19）旅行限制，且疫苗接种率仅为2.7%，但海地疫情的时间和谱系演变与世界其他地区的情况相似。传入海地的谱系来源包括美国、多米尼加共和国、欧洲和巴西，传出的谱系则流向美国、多米尼加共和国、欧洲和亚洲。在系统发育树上，感染德尔塔和奥密克戎BA.1变体的患者的病毒载量具有相关性，这表明较高的病毒载量促进了毒株的传播和进化。
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