Torun Aydan, Tuğral Hoşnaz, Banerjee Sreeparna
Department of Biological Sciences, Orta Dogu Teknik Universitesi, Ankara, Türkiye.
Adv Exp Med Biol. 2025;1483:141-169. doi: 10.1007/5584_2025_852.
Compartmentalization in eukaryotic cells allows the spatiotemporal regulation of biochemical processes, in addition to allowing specific sets of proteins to interact in a regulated as well as stochastic manner. Although membrane-bound organelles are thought to be the key players of cellular compartmentalization, membraneless biomolecular condensates such as stress granules, P bodies, and many others have recently emerged as key players that are also thought to bring order to a highly chaotic environment. Here, we have evaluated the latest studies on biomolecular condensates, specifically focusing on how they interact with membrane-bound organelles and modulate each other's functions. We also highlight the importance of this interaction in neurodegenerative and cardiovascular diseases as well as in cancer.
真核细胞中的区室化不仅允许特定的蛋白质组以受调控以及随机的方式相互作用，还能实现生化过程的时空调节。尽管膜结合细胞器被认为是细胞区室化的关键参与者，但诸如应激颗粒、P小体等无膜生物分子凝聚物最近也成为关键参与者，它们也被认为能为高度混乱的环境带来秩序。在这里，我们评估了关于生物分子凝聚物的最新研究，特别关注它们如何与膜结合细胞器相互作用并调节彼此的功能。我们还强调了这种相互作用在神经退行性疾病、心血管疾病以及癌症中的重要性。
