Department of Radiology, West China Biomedical Big Data Center, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041, China.
West China Biomedical Big Data Center, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041, China.
Cereb Cortex. 2024 Oct 3;34(10). doi: 10.1093/cercor/bhae423.
We aimed to longitudinally examine the relationship between depression and cognitive function and investigate the mediating effects of imaging indicators in this relationship. 2,251 subjects with longitudinal assessment of geriatric depression scale, Mini-Mental State Examination, Montreal Cognitive Assessment, Clinical Dementia Rating-Sum of Boxes (CDRSB), Alzheimer's Disease Assessment Scale11, Alzheimer's Disease Assessment Scale13 and imaging of 3DT1, diffusion tensor imaging, fluid-attenuated inversion recovery, arterial spin labeling, fluorodeoxyglucose positron emission tomography, 18F-AV45-PET, and 18F-AV1451-PET were included from the Alzheimer's Disease Neuroimaging Initiative database. The multivariate mixed-effects models were employed to analyze the correlation between geriatric depression scale scores, cognitive function, and imaging indicators. The sgmediation software package was utilized to analyze the mediating effects of imaging indicators. The geriatric depression scale was negatively correlated with Mini-Mental State Examination and Montreal Cognitive Assessment, and positively correlated with CDRSB, Alzheimer's Disease Assessment Scale11, and Alzheimer's Disease Assessment Scale13 when the subjects were not grouped. The geriatric depression scale was negatively correlated with Montreal Cognitive Assessment and positively correlated with Alzheimer's Disease Assessment Scal13 in groups with baseline diagnosis of early mild cognitive impairment and late mild cognitive impairment. Furthermore, depression was associated with regional imaging indicators, while cognitive function was linked to broad imaging indicators. Some of these indicators were related to both depression and cognitive function, playing a mediating role in their relationship. Depression was related to cognitive function, especially in subjects with mild cognitive impairment. Some imaging indicators may represent the underlying basis for the association between depression and cognitive function.
我们旨在纵向研究抑郁与认知功能之间的关系，并探讨该关系中影像学指标的中介作用。2251 名受试者接受了老年抑郁量表、简易精神状态检查、蒙特利尔认知评估、临床痴呆评定量表总和分（CDRSB）、阿尔茨海默病评估量表 11 分、阿尔茨海默病评估量表 13 分以及 3DT1、弥散张量成像、液体衰减反转恢复、动脉自旋标记、氟脱氧葡萄糖正电子发射断层扫描、18F-AV45-PET 和 18F-AV1451-PET 影像学检查的纵向评估，这些数据均来自阿尔茨海默病神经影像学倡议数据库。采用多变量混合效应模型分析老年抑郁量表评分、认知功能与影像学指标之间的相关性。利用 sgmediation 软件包分析影像学指标的中介作用。当受试者未分组时，老年抑郁量表与简易精神状态检查和蒙特利尔认知评估呈负相关，与 CDRSB、阿尔茨海默病评估量表 11 分和阿尔茨海默病评估量表 13 分呈正相关。在基线诊断为早期轻度认知障碍和晚期轻度认知障碍的组中，老年抑郁量表与蒙特利尔认知评估呈负相关，与阿尔茨海默病评估量表 13 分呈正相关。此外，抑郁与区域影像学指标相关，而认知功能与广泛的影像学指标相关。其中一些指标与抑郁和认知功能均相关，在它们的关系中发挥中介作用。抑郁与认知功能有关，尤其是在轻度认知障碍患者中。一些影像学指标可能代表抑郁与认知功能之间关联的潜在基础。
