Teichgraeber Davis C, Bassett Roland L, Whitman Gary J
Department of Breast Imaging, The University of Texas MD Anderson Cancer, Houston, TX, USA.
Department of Biostatistics, The University of Texas MD Anderson Cancer, Houston, TX, USA.
J Breast Imaging. 2025 Jan 25;7(1):27-34. doi: 10.1093/jbi/wbae059.
The purpose of this study was to evaluate the utility of US for identifying and characterizing lesions detected on molecular breast imaging (MBI).
A retrospective single-institution review was performed of patients with MBI studies with subsequent US for abnormal MBI findings between January 1, 2015, and September 30, 2021. Medical records, imaging, and histopathology were reviewed. The reference standard was histopathology and/or imaging follow-up. Associations among MBI findings, the presence of an US correlate, and histopathology were evaluated by Fisher exact tests.
The 32 lesions detected on MBI in 25 patients were evaluated by US, and 19 lesions had an US correlate (19/32, 59%). Mass uptake was more likely to have an US correlate (11/13, 85%; P = .02) than nonmass uptake (7/19, 37%), and mass uptake was more likely to be malignant (5/13, 38%; P = .01). Of the 13 lesions without an US correlate, 5 were evaluated and subsequently biopsied by MRI (2 high-risk lesions and 3 benign lesions). Follow-up MBIs demonstrated stability/resolution for 5 lesions in 4 patients at 6 months or longer. Three patients had no further imaging.
Mass lesions identified on MBI were more likely to have an US correlate and were more likely to be malignant than nonmass lesions.
本研究的目的是评估超声用于识别和表征分子乳腺成像（MBI）检测到的病变的效用。
对2015年1月1日至2021年9月30日期间进行MBI检查且随后因MBI异常结果接受超声检查的患者进行单机构回顾性研究。回顾了病历、影像学和组织病理学资料。参考标准为组织病理学和/或影像学随访。通过Fisher精确检验评估MBI结果、超声相关性的存在与组织病理学之间的关联。
对25例患者MBI检测到的32个病变进行了超声评估，其中19个病变有超声相关性（19/32，59%）。与非肿块摄取相比，肿块摄取更可能有超声相关性（11/13，85%；P = 0.02），且肿块摄取更可能为恶性（5/13，38%；P = 0.01）。在13个无超声相关性的病变中，5个接受了MRI评估并随后进行了活检（2个高危病变和3个良性病变）。随访MBI显示4例患者的5个病变在6个月或更长时间内稳定/消退。3例患者未进行进一步影像学检查。
MBI识别出的肿块性病变比非肿块性病变更可能有超声相关性，且更可能为恶性。
